TY - JOUR
T1 - Interaction between tobacco and alcohol use and the risk of head and neck cancer
T2 - Pooled analysis in the international head and neck cancer Epidemiology consortium
AU - Hashibe, Mia
AU - Brennan, Paul
AU - Chuang, Shu Chun
AU - Boccia, Stefania
AU - Castellsague, Xavier
AU - Chen, Chu
AU - Curado, Maria Paula
AU - Maso, Luigino Dal
AU - Daudt, Alexander W.
AU - Fabianova, Eleonora
AU - Fernandez, Leticia
AU - Wünsch-Filho, Victor
AU - Franceschi, Silvia
AU - Hayes, Richard B.
AU - Herrero, Rolando
AU - Kelsey, Karl
AU - Koifman, Sergio
AU - Vecchia, Carlo La
AU - Lazarus, Philip
AU - Levi, Fabio
AU - Lence, Juan J.
AU - Mates, Dana
AU - Matos, Elena
AU - Menezes, Ana
AU - McClean, Michael D.
AU - Muscat, Joshua
AU - Eluf-Neto, Jose
AU - Olshan, Andrew F.
AU - Purdue, Mark
AU - Rudnai, Peter
AU - Schwartz, Stephen M.
AU - Smith, Elaine
AU - Sturgis, Erich M.
AU - Szeszenia-Dabrowska, Neonilia
AU - Talamini, Renato
AU - Wei, Qingyi
AU - Winn, Deborah M.
AU - Shangina, Oxana
AU - Pilarska, Agnieszka
AU - Zhang, Zuo Feng
AU - Ferro, Gilles
AU - Berthiller, Julien
AU - Boffetta, Paolo
PY - 2009/2
Y1 - 2009/2
N2 - Background: The magnitude of risk conferred by the interaction between tobacco and alcohol use on the risk of head and neck cancers is not clear because studies have used various methods to quantify the excess head and neck cancer burden. Methods: We analyzed individual-level pooled data from 17 European and American case-control studies (11,221 cases and 16,168 controls) participating in the International Head and Neck Cancer Epidemiology consortium. We estimated the multiplicative interaction parameter (ψ) and population attributable risks (PAR). Results: A greater than multiplicative joint effect between ever tobacco and alcohol use was observed for head and neck cancer risk (ψ = 2.15; 95% confidence interval, 1.53-3.04). The PAR for tobacco or alcohol was 72% (95% confidence interval, 61-79%) for head and neck cancer, of which 4% was due to alcohol alone, 33% was due to tobacco alone, and 35% was due to tobacco and alcohol combined. The total PAR differed by subsite (64% for oral cavity cancer, 72% for pharyngeal cancer, 89% for laryngeal cancer), by sex (74% for men, 57% for women), by age (33% for cases <45 years, 73% for cases >60 years), and by region (84% in Europe, 51% in North America, 83% in Latin America). Conclusions: Our results confirm that the joint effect between tobacco and alcohol use is greater than multiplicative on head and neck cancer risk. However, a substantial proportion of head and neck cancers cannot be attributed to tobacco or alcohol use, particularly for oral cavity cancer and for head and neck cancer among women and among young-onset cases.
AB - Background: The magnitude of risk conferred by the interaction between tobacco and alcohol use on the risk of head and neck cancers is not clear because studies have used various methods to quantify the excess head and neck cancer burden. Methods: We analyzed individual-level pooled data from 17 European and American case-control studies (11,221 cases and 16,168 controls) participating in the International Head and Neck Cancer Epidemiology consortium. We estimated the multiplicative interaction parameter (ψ) and population attributable risks (PAR). Results: A greater than multiplicative joint effect between ever tobacco and alcohol use was observed for head and neck cancer risk (ψ = 2.15; 95% confidence interval, 1.53-3.04). The PAR for tobacco or alcohol was 72% (95% confidence interval, 61-79%) for head and neck cancer, of which 4% was due to alcohol alone, 33% was due to tobacco alone, and 35% was due to tobacco and alcohol combined. The total PAR differed by subsite (64% for oral cavity cancer, 72% for pharyngeal cancer, 89% for laryngeal cancer), by sex (74% for men, 57% for women), by age (33% for cases <45 years, 73% for cases >60 years), and by region (84% in Europe, 51% in North America, 83% in Latin America). Conclusions: Our results confirm that the joint effect between tobacco and alcohol use is greater than multiplicative on head and neck cancer risk. However, a substantial proportion of head and neck cancers cannot be attributed to tobacco or alcohol use, particularly for oral cavity cancer and for head and neck cancer among women and among young-onset cases.
UR - http://www.scopus.com/inward/record.url?scp=60549117324&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-08-0347
DO - 10.1158/1055-9965.EPI-08-0347
M3 - Article
C2 - 19190158
AN - SCOPUS:60549117324
SN - 1055-9965
VL - 18
SP - 541
EP - 550
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 2
ER -