TY - JOUR
T1 - Interaction between SERTPR and stressful life events on response to antidepressant treatment
AU - Mandelli, Laura
AU - Marino, Elena
AU - Pirovano, Adele
AU - Calati, Raffaella
AU - Zanardi, Raffaella
AU - Colombo, Cristina
AU - Serretti, Alessandro
PY - 2009/1
Y1 - 2009/1
N2 - A polymorphism within the serotonin transporter gene (SERTPR) has been repeatedly associated to mood disorders and response to SSRIs treatment. Recent evidence suggested that influence of genetic effect of SERTPR might be modulated by stress, particularly as regard the development of anxious-depressive symptoms. Nevertheless, there is no information about the role of stressors as potential modulator of SERTPR effects on depressive outcome during pharmacological treatment. In a sample of 159 mood disorder patients treated with fluvoxamine, we found stressors preceding the onset of the illness significantly influencing the genetic effect exerted by SERTPR on response after 6 weeks of treatment. This preliminary finding supports the idea of complex interaction between biological and environmental factors underlying the efficacy of biological treatments, other than liability for mood disorders. Nevertheless, many limitations characterize the present investigation and well-funded studies on larger samples are required.
AB - A polymorphism within the serotonin transporter gene (SERTPR) has been repeatedly associated to mood disorders and response to SSRIs treatment. Recent evidence suggested that influence of genetic effect of SERTPR might be modulated by stress, particularly as regard the development of anxious-depressive symptoms. Nevertheless, there is no information about the role of stressors as potential modulator of SERTPR effects on depressive outcome during pharmacological treatment. In a sample of 159 mood disorder patients treated with fluvoxamine, we found stressors preceding the onset of the illness significantly influencing the genetic effect exerted by SERTPR on response after 6 weeks of treatment. This preliminary finding supports the idea of complex interaction between biological and environmental factors underlying the efficacy of biological treatments, other than liability for mood disorders. Nevertheless, many limitations characterize the present investigation and well-funded studies on larger samples are required.
KW - Gene x environment interaction
KW - Response to SSRIs
KW - SERTPR
KW - Stressful life events
UR - https://www.scopus.com/pages/publications/57049093901
U2 - 10.1016/j.euroneuro.2008.08.005
DO - 10.1016/j.euroneuro.2008.08.005
M3 - Article
C2 - 18815011
AN - SCOPUS:57049093901
SN - 0924-977X
VL - 19
SP - 64
EP - 67
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 1
ER -