Intensive metabolic support: Evolution and revolution

Corey Scurlock, Jayashree Raikhelkar, Jeffrey I. Mechanick

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Objective: To describe a new aspect of critical care termed intensive metabolic support. Methods: We performed a MEDLINE search of the English-language literature published between 1995 and 2008 for studies regarding the metabolic stages of critical illness, intensive insulin treatment, and intensive metabolic support in the intensive care unit, and we summarize the clinical data. Results: Intensive metabolic support is a 3-component model involving metabolic control and intensive insulin therapy, early nutrition support, and nutritional pharmacology aimed at preventing allostatic overload and the development of chronic critical illness. To improve clinical outcome and prevent mortality, intensive metabolic support should start on arrival to the intensive care unit and should end only when patients are in the recovery phase of their illness. Conclusions: Intensive metabolic support should be an essential part of the daily treatment strategy in critical care medicine. This will involve a newfound and extensive collaboration between the endocrinologist and the intensivist. We call for well-designed future studies involving implementation of this protocol to decrease the burden of chronic critical illness.

Original languageEnglish
Pages (from-to)1047-1054
Number of pages8
JournalEndocrine Practice
Issue number8
StatePublished - Nov 2008


Dive into the research topics of 'Intensive metabolic support: Evolution and revolution'. Together they form a unique fingerprint.

Cite this