TY - JOUR
T1 - Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
AU - Gao, Jianjiong
AU - Aksoy, Bülent Arman
AU - Dogrusoz, Ugur
AU - Dresdner, Gideon
AU - Gross, Benjamin
AU - Sumer, S. Onur
AU - Sun, Yichao
AU - Jacobsen, Anders
AU - Sinha, Rileen
AU - Larsson, Erik
AU - Cerami, Ethan
AU - Sander, Chris
AU - Schultz, Nikolaus
PY - 2013/4/2
Y1 - 2013/4/2
N2 - The cBioPortal for Cancer Genomics (http://cbioportal.org) provides a Web resource for exploring, visualizing, and analyzing multidimensional cancer genomics data. The portal reduces molecular profiling data from cancer tissues and cell lines into readily understandable genetic, epigenetic, gene expression, and proteomic events. The query interface combined with customized data storage enables researchers to interactively explore genetic alterations across samples, genes, and pathways and, when available in the underlying data, to link these to clinical outcomes. The portal provides graphical summaries of gene-level data from multiple platforms, network visualization and analysis, survival analysis, patient-centric queries, and software programmatic access. The intuitive Web interface of the portal makes complex cancer genomics profiles accessible to researchers and clinicians without requiring bioinformatics expertise, thus facilitating biological discoveries. Here, we provide a practical guide to the analysis and visualization features of the cBioPortal for Cancer Genomics.
AB - The cBioPortal for Cancer Genomics (http://cbioportal.org) provides a Web resource for exploring, visualizing, and analyzing multidimensional cancer genomics data. The portal reduces molecular profiling data from cancer tissues and cell lines into readily understandable genetic, epigenetic, gene expression, and proteomic events. The query interface combined with customized data storage enables researchers to interactively explore genetic alterations across samples, genes, and pathways and, when available in the underlying data, to link these to clinical outcomes. The portal provides graphical summaries of gene-level data from multiple platforms, network visualization and analysis, survival analysis, patient-centric queries, and software programmatic access. The intuitive Web interface of the portal makes complex cancer genomics profiles accessible to researchers and clinicians without requiring bioinformatics expertise, thus facilitating biological discoveries. Here, we provide a practical guide to the analysis and visualization features of the cBioPortal for Cancer Genomics.
UR - http://www.scopus.com/inward/record.url?scp=84875740314&partnerID=8YFLogxK
U2 - 10.1126/scisignal.2004088
DO - 10.1126/scisignal.2004088
M3 - Article
C2 - 23550210
AN - SCOPUS:84875740314
SN - 1945-0877
VL - 6
SP - pl1
JO - Science Signaling
JF - Science Signaling
IS - 269
ER -