Integration of evidence across human and model organism studies: A meeting report

Rohan H.C. Palmer, Emma C. Johnson, Hyejung Won, Renato Polimanti, Manav Kapoor, Apurva Chitre, Molly A. Bogue, Chelsie E. Benca-Bachman, Clarissa C. Parker, Anurag Verma, Timothy Reynolds, Jason Ernst, Michael Bray, Soo Bin Kwon, Dongbing Lai, Bryan C. Quach, Nathan C. Gaddis, Laura Saba, Hao Chen, Michael HawrylyczShan Zhang, Yuan Zhou, Spencer Mahaffey, Christian Fischer, Sandra Sanchez-Roige, Anita Bandrowski, Qing Lu, Li Shen, Vivek Philip, Joel Gelernter, Laura J. Bierut, Dana B. Hancock, Howard J. Edenberg, Eric O. Johnson, Eric J. Nestler, Peter B. Barr, Pjotr Prins, Desmond J. Smith, Schahram Akbarian, Thorgeir Thorgeirsson, Dave Walton, Erich Baker, Daniel Jacobson, Abraham A. Palmer, Michael Miles, Elissa J. Chesler, Jake Emerson, Arpana Agrawal, Maryann Martone, Robert W. Williams

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


The National Institute on Drug Abuse and Joint Institute for Biological Sciences at the Oak Ridge National Laboratory hosted a meeting attended by a diverse group of scientists with expertise in substance use disorders (SUDs), computational biology, and FAIR (Findability, Accessibility, Interoperability, and Reusability) data sharing. The meeting's objective was to discuss and evaluate better strategies to integrate genetic, epigenetic, and 'omics data across human and model organisms to achieve deeper mechanistic insight into SUDs. Specific topics were to (a) evaluate the current state of substance use genetics and genomics research and fundamental gaps, (b) identify opportunities and challenges of integration and sharing across species and data types, (c) identify current tools and resources for integration of genetic, epigenetic, and phenotypic data, (d) discuss steps and impediment related to data integration, and (e) outline future steps to support more effective collaboration—particularly between animal model research communities and human genetics and clinical research teams. This review summarizes key facets of this catalytic discussion with a focus on new opportunities and gaps in resources and knowledge on SUDs.

Original languageEnglish
JournalGenes, Brain and Behavior
StateAccepted/In press - 2021


  • GWAS
  • cross-species
  • data integration
  • drug abuse
  • genomics
  • model organisms
  • multi-omic
  • substance use disorders
  • working group


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