@article{13599471b8474d5aa7692d5a007b1172,
title = "Integration of evidence across human and model organism studies: A meeting report",
abstract = "The National Institute on Drug Abuse and Joint Institute for Biological Sciences at the Oak Ridge National Laboratory hosted a meeting attended by a diverse group of scientists with expertise in substance use disorders (SUDs), computational biology, and FAIR (Findability, Accessibility, Interoperability, and Reusability) data sharing. The meeting's objective was to discuss and evaluate better strategies to integrate genetic, epigenetic, and 'omics data across human and model organisms to achieve deeper mechanistic insight into SUDs. Specific topics were to (a) evaluate the current state of substance use genetics and genomics research and fundamental gaps, (b) identify opportunities and challenges of integration and sharing across species and data types, (c) identify current tools and resources for integration of genetic, epigenetic, and phenotypic data, (d) discuss steps and impediment related to data integration, and (e) outline future steps to support more effective collaboration—particularly between animal model research communities and human genetics and clinical research teams. This review summarizes key facets of this catalytic discussion with a focus on new opportunities and gaps in resources and knowledge on SUDs.",
keywords = "GWAS, cross-species, data integration, drug abuse, genomics, model organisms, multi-omic, substance use disorders, working group",
author = "Palmer, {Rohan H.C.} and Johnson, {Emma C.} and Hyejung Won and Renato Polimanti and Manav Kapoor and Apurva Chitre and Bogue, {Molly A.} and Benca-Bachman, {Chelsie E.} and Parker, {Clarissa C.} and Anurag Verma and Timothy Reynolds and Jason Ernst and Michael Bray and Kwon, {Soo Bin} and Dongbing Lai and Quach, {Bryan C.} and Gaddis, {Nathan C.} and Laura Saba and Hao Chen and Michael Hawrylycz and Shan Zhang and Yuan Zhou and Spencer Mahaffey and Christian Fischer and Sandra Sanchez-Roige and Anita Bandrowski and Qing Lu and Li Shen and Vivek Philip and Joel Gelernter and Bierut, {Laura J.} and Hancock, {Dana B.} and Edenberg, {Howard J.} and Johnson, {Eric O.} and Nestler, {Eric J.} and Barr, {Peter B.} and Pjotr Prins and Smith, {Desmond J.} and Schahram Akbarian and Thorgeir Thorgeirsson and Dave Walton and Erich Baker and Daniel Jacobson and Palmer, {Abraham A.} and Michael Miles and Chesler, {Elissa J.} and Jake Emerson and Arpana Agrawal and Maryann Martone and Williams, {Robert W.}",
note = "Funding Information: This work was supported by grants from the National Institute on Drug Abuse (DP1 DA042103 [awarded to: Rohan H. C. Palmer], P30DA044223 [Li Shen & Robert W. Williams], R01 DA051913 [Dana B. Hancock & Daniel Jacobson]), R01 DA051908 (Eric O. Johnson & Daniel Jacobson), U01 DA048279 (Schahram Akbarian), R21 DA051921 (Hyejung Won), DP1 DA044371 (Jason Ernst), U01 DA041602 (Desmond J. Smith), P50DA037844 (Abraham A. Palmer), DA028420 (Michael Bray), DA045401 (Molly A. Bogue), K02 DA032573 (Arpana Agrawal), R21 DA047527 (Renato Polimanti), R15 DA041618 (Clarissa C. Parker), U24 DA039832 (Michael Miles), PGC‐SUD support (MH109532 [Elissa J. Chesler, Renato Polimanti, Joel Gelernter, Howard J. Edenberg, Arpana Agrawal]), and The University of Tennessee Center for Integrative and Translational Genomics [Robert W. Williams]. Authors would like to thank Drs. Amy Lossie, Jonathan Pollock, Susan Wright, Roger Little and Marti Head for their excellent organization of the workshop and their encouragement in assembling this report. We gratefully acknowledge Ms. Michelle Myers of RTI International for editorial assistance and Ms. Maia Amellio of Emory University for editorial assistance, as well as Dr. Megan Mulligan of The Health Science Center, University of Tennessee for her assistance with the planning of the meeting. The graphical abstract for this publication was created by Dr. David Kainer (at Oak Ridge National Laboratory) with BioRender.com. Publisher Copyright: {\textcopyright} 2021 The Authors. Genes, Brain and Behavior published by International Behavioural and Neural Genetics Society and John Wiley & Sons Ltd.",
year = "2021",
doi = "10.1111/gbb.12738",
language = "English",
journal = "Genes, Brain and Behavior",
issn = "1601-1848",
publisher = "Wiley-Blackwell Publishing Ltd",
}