@article{87222ef41fd643c1a85aeb3e3c836cc6,
title = "Integrating Interleukin-6 into depression diagnosis and treatment",
abstract = "There is growing evidence of a relationship between inflammation and psychiatric illness. In particular, the cytokine Interleukin-6 (IL-6) has been linked to stress-related disorders such as depression and anxiety. Here we discuss evidence from preclinical and clinical studies examining the role of IL-6 in mood disorders. We focus on the functional role of peripheral and central release of IL-6 on the development of stress susceptibility and depression-associated behavior. By examining the contribution of both peripheral and central IL-6 to manifestations of stress-related symptomatology, we hope to broaden the way the field thinks about diagnosing and treating mood disorders.",
author = "Hodes, {Georgia E.} and Caroline M{\'e}nard and Russo, {Scott J.}",
note = "Funding Information: The authors thank Madeline Pfau for her assistance with editing the manuscript. We would like to acknowledge the following support: R01MH104559, R01MH090264 and R21MH099562 to SJR. Brain and behavior research foundation NARSAD young investigator award to GEH. This publication was supported by Grant Number P50 AT008661-01, titled ?Dietary Botanicals in the Preservation of Cognitive and Psychological Resilience,? from the National Center for Complementary and Integrative Health (NCCIH) and the Office of Dietary Supplements (ODS). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NCCIH, ODS, or the National Institutes of Health. Funding Information: The authors thank Madeline Pfau for her assistance with editing the manuscript. We would like to acknowledge the following support: R01MH104559, R01MH090264 and R21MH099562 to SJR. Brain and behavior research foundation NARSAD young investigator award to GEH. This publication was supported by Grant Number P50 AT008661-01 , titled “Dietary Botanicals in the Preservation of Cognitive and Psychological Resilience,” from the National Center for Complementary and Integrative Health (NCCIH) and the Office of Dietary Supplements (ODS) . Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NCCIH, ODS, or the National Institutes of Health. Publisher Copyright: {\textcopyright} 2016",
year = "2016",
month = oct,
day = "1",
doi = "10.1016/j.ynstr.2016.03.003",
language = "English",
volume = "4",
pages = "15--22",
journal = "Neurobiology of Stress",
issn = "2352-2895",
publisher = "Elsevier BV",
}