Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation

Kidney Precision Medicine Project

doi:10.1016/j.kint.2022.03.011

Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation

Kidney Precision Medicine Project

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Original language	English
Pages (from-to)	1116-1125
Number of pages	10
Journal	Kidney International
Volume	101
Issue number	6
DOIs	https://doi.org/10.1016/j.kint.2022.03.011
State	Published - Jun 2022

Keywords

AKI
Kidney Precision Medicine Project
NSAID
kidney
single-cell sequencing

Access to Document

10.1016/j.kint.2022.03.011

Cite this

@article{318a935343d04b38a6bce3d0e54dcf07,

title = "Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation",

keywords = "AKI, Kidney Precision Medicine Project, NSAID, kidney, single-cell sequencing",

author = "{Kidney Precision Medicine Project} and Rajasree Menon and Bomback, {Andrew S.} and Lake, {Blue B.} and Christy Stutzke and Grewenow, {Stephanie M.} and Steven Menez and D'Agati, {Vivette D.} and Sanjay Jain and Richard Knight and Lecker, {Stewart H.} and Isaac Stillman and Steve Bogen and Beck, {Laurence H.} and Sushrut Waikar and McMahon, {Gearoid M.} and Astrid Weins and Colona, {Mia R.} and Nir Hacohen and Hoover, {Paul J.} and Mark Aulisio and Bush, {William S.} and Crawford, {Dana C.} and John O'toole and Emilio Poggio and John Sedor and Leslie Cooperman and Stacey Jolly and Leal Herlitz and Jane Nguyen and Agustin Gonzalez-Vicente and Ellen Palmer and Dianna Sendrey and Carissa Vinovskis and Bjornstad, {Petter M.} and Paul Appelbaum and Barasch, {Jonathan M.} and D'Agati, {Vivette D.} and Krzysztof Kiryluk and Karla Mehl and Canetta, {Pietro A.} and Ning Shang and Olivia Balderes and Satoru Kudose and Shweta Bansal and Theodore Alexandrov and Helmut Rennke and El-Achkar, {Tarek M.} and Azeloglu, {Evren U.} and Ravi Iyengar and Jens Hansen",

note = "Funding Information: We are deeply indebted to the generosity of KPMP participants who volunteer to donate tissue primarily for research purposes despite no direct immediate benefit to their clinical care. We are grateful to clinical coordinators Karla Mehl and Olivia Balderes for efforts in study participant recruitments, specimen procurement, and data collection. We thank the KPMP CPMC working group for guidance with this case presentation. Research reported in this paper was supported by the National Institute of Diabetes and Digestive and Kidney Diseases ( NIDDK ) KPMP ( www.kpmp.org ), under award numbers U2C DK114886 , UH3DK114861 , UH3DK114866 , UH3DK114870 , UH3DK114908 , UH3DK114915 , UH3DK114926 , UH3DK114907 , UH3DK114923 , and UH3DK114933 , and HuBMAP grant U54HL145608 (SJ). ",

year = "2022",

month = jun,

doi = "10.1016/j.kint.2022.03.011",

language = "English",

volume = "101",

pages = "1116--1125",

journal = "Kidney International",

issn = "0085-2538",

publisher = "Elsevier Inc.",

number = "6",

}

TY - JOUR

T1 - Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury

T2 - a clinical-molecular-pathologic correlation

AU - Kidney Precision Medicine Project

AU - Menon, Rajasree

AU - Bomback, Andrew S.

AU - Lake, Blue B.

AU - Stutzke, Christy

AU - Grewenow, Stephanie M.

AU - Menez, Steven

AU - D'Agati, Vivette D.

AU - Jain, Sanjay

AU - Knight, Richard

AU - Lecker, Stewart H.

AU - Stillman, Isaac

AU - Bogen, Steve

AU - Beck, Laurence H.

AU - Waikar, Sushrut

AU - McMahon, Gearoid M.

AU - Weins, Astrid

AU - Colona, Mia R.

AU - Hacohen, Nir

AU - Hoover, Paul J.

AU - Aulisio, Mark

AU - Bush, William S.

AU - Crawford, Dana C.

AU - O'toole, John

AU - Poggio, Emilio

AU - Sedor, John

AU - Cooperman, Leslie

AU - Jolly, Stacey

AU - Herlitz, Leal

AU - Nguyen, Jane

AU - Gonzalez-Vicente, Agustin

AU - Palmer, Ellen

AU - Sendrey, Dianna

AU - Vinovskis, Carissa

AU - Bjornstad, Petter M.

AU - Appelbaum, Paul

AU - Barasch, Jonathan M.

AU - D'Agati, Vivette D.

AU - Kiryluk, Krzysztof

AU - Mehl, Karla

AU - Canetta, Pietro A.

AU - Shang, Ning

AU - Balderes, Olivia

AU - Kudose, Satoru

AU - Bansal, Shweta

AU - Alexandrov, Theodore

AU - Rennke, Helmut

AU - El-Achkar, Tarek M.

AU - Azeloglu, Evren U.

AU - Iyengar, Ravi

AU - Hansen, Jens

N1 - Funding Information: We are deeply indebted to the generosity of KPMP participants who volunteer to donate tissue primarily for research purposes despite no direct immediate benefit to their clinical care. We are grateful to clinical coordinators Karla Mehl and Olivia Balderes for efforts in study participant recruitments, specimen procurement, and data collection. We thank the KPMP CPMC working group for guidance with this case presentation. Research reported in this paper was supported by the National Institute of Diabetes and Digestive and Kidney Diseases ( NIDDK ) KPMP ( www.kpmp.org ), under award numbers U2C DK114886 , UH3DK114861 , UH3DK114866 , UH3DK114870 , UH3DK114908 , UH3DK114915 , UH3DK114926 , UH3DK114907 , UH3DK114923 , and UH3DK114933 , and HuBMAP grant U54HL145608 (SJ).

PY - 2022/6

Y1 - 2022/6

KW - AKI

KW - Kidney Precision Medicine Project

KW - NSAID

KW - kidney

KW - single-cell sequencing

UR - http://www.scopus.com/inward/record.url?scp=85129820602&partnerID=8YFLogxK

U2 - 10.1016/j.kint.2022.03.011

DO - 10.1016/j.kint.2022.03.011

M3 - Article

C2 - 35339536

AN - SCOPUS:85129820602

SN - 0085-2538

VL - 101

SP - 1116

EP - 1125

JO - Kidney International

JF - Kidney International

IS - 6

ER -