Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma

Qiang Gao; Hongwen Zhu; Liangqing Dong; Weiwei Shi; Ran Chen; Zhijian Song; Chen Huang; Junqiang Li; Xiaowei Dong; Yanting Zhou; Qian Liu; Lijie Ma; Xiaoying Wang; Jian Zhou; Yansheng Liu; Emily Boja; Ana I. Robles; Weiping Ma; Pei Wang; Yize Li; Li Ding; Bo Wen; Bing Zhang; Henry Rodriguez; Daming Gao; Hu Zhou; Jia Fan

doi:10.1016/j.cell.2019.08.052

Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma

Qiang Gao
, Hongwen Zhu
, Liangqing Dong
, Weiwei Shi
, Ran Chen
, Zhijian Song
, Chen Huang
, Junqiang Li
, Xiaowei Dong
, Yanting Zhou
, Qian Liu
, Lijie Ma
, Xiaoying Wang
, Jian Zhou
, Yansheng Liu
, Emily Boja
, Ana I. Robles
, Weiping Ma
, Pei Wang
, Yize Li

Li Ding, Bo Wen, Bing Zhang, Henry Rodriguez, Daming Gao, Hu Zhou, Jia Fan

Research output: Contribution to journal › Article › peer-review

772 Scopus citations

Abstract

Proteogenomic characterization of HBV-related hepatocellular carcinoma (HCC) using paired tumor and adjacent liver tissues identifies three subgroups with distinct features in metabolic reprogramming, microenvironment dysregulation, cell proliferation, and potential therapeutics.

Original language	English
Pages (from-to)	561-577.e22
Journal	Cell
Volume	179
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2019.08.052
State	Published - 3 Oct 2019

Keywords

AA signature
ALDOA
CTNNB1
hepaotcellular carcinoma
metabolism
neoantigen
prognosis
proteogenomics
proteomics

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10.1016/j.cell.2019.08.052

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@article{4a873616720c4eb2b1e2977b55029301,

title = "Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma",

abstract = "Proteogenomic characterization of HBV-related hepatocellular carcinoma (HCC) using paired tumor and adjacent liver tissues identifies three subgroups with distinct features in metabolic reprogramming, microenvironment dysregulation, cell proliferation, and potential therapeutics.",

keywords = "AA signature, ALDOA, CTNNB1, hepaotcellular carcinoma, metabolism, neoantigen, prognosis, proteogenomics, proteomics",

author = "Qiang Gao and Hongwen Zhu and Liangqing Dong and Weiwei Shi and Ran Chen and Zhijian Song and Chen Huang and Junqiang Li and Xiaowei Dong and Yanting Zhou and Qian Liu and Lijie Ma and Xiaoying Wang and Jian Zhou and Yansheng Liu and Emily Boja and Robles, \{Ana I.\} and Weiping Ma and Pei Wang and Yize Li and Li Ding and Bo Wen and Bing Zhang and Henry Rodriguez and Daming Gao and Hu Zhou and Jia Fan",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = oct,

day = "3",

doi = "10.1016/j.cell.2019.08.052",

language = "English",

volume = "179",

pages = "561--577.e22",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "2",

}

Gao, Q, Zhu, H, Dong, L, Shi, W, Chen, R, Song, Z, Huang, C, Li, J, Dong, X, Zhou, Y, Liu, Q, Ma, L, Wang, X, Zhou, J, Liu, Y, Boja, E, Robles, AI, Ma, W, Wang, P, Li, Y, Ding, L, Wen, B, Zhang, B, Rodriguez, H, Gao, D, Zhou, H & Fan, J 2019, 'Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma', Cell, vol. 179, no. 2, pp. 561-577.e22. https://doi.org/10.1016/j.cell.2019.08.052

TY - JOUR

T1 - Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma

AU - Gao, Qiang

AU - Zhu, Hongwen

AU - Dong, Liangqing

AU - Shi, Weiwei

AU - Chen, Ran

AU - Song, Zhijian

AU - Huang, Chen

AU - Li, Junqiang

AU - Dong, Xiaowei

AU - Zhou, Yanting

AU - Liu, Qian

AU - Ma, Lijie

AU - Wang, Xiaoying

AU - Zhou, Jian

AU - Liu, Yansheng

AU - Boja, Emily

AU - Robles, Ana I.

AU - Ma, Weiping

AU - Wang, Pei

AU - Li, Yize

AU - Ding, Li

AU - Wen, Bo

AU - Zhang, Bing

AU - Rodriguez, Henry

AU - Gao, Daming

AU - Zhou, Hu

AU - Fan, Jia

PY - 2019/10/3

Y1 - 2019/10/3

N2 - Proteogenomic characterization of HBV-related hepatocellular carcinoma (HCC) using paired tumor and adjacent liver tissues identifies three subgroups with distinct features in metabolic reprogramming, microenvironment dysregulation, cell proliferation, and potential therapeutics.

AB - Proteogenomic characterization of HBV-related hepatocellular carcinoma (HCC) using paired tumor and adjacent liver tissues identifies three subgroups with distinct features in metabolic reprogramming, microenvironment dysregulation, cell proliferation, and potential therapeutics.

KW - AA signature

KW - ALDOA

KW - CTNNB1

KW - hepaotcellular carcinoma

KW - metabolism

KW - neoantigen

KW - prognosis

KW - proteogenomics

KW - proteomics

UR - https://www.scopus.com/pages/publications/85072513635

U2 - 10.1016/j.cell.2019.08.052

DO - 10.1016/j.cell.2019.08.052

M3 - Article

C2 - 31585088

AN - SCOPUS:85072513635

SN - 0092-8674

VL - 179

SP - 561-577.e22

JO - Cell

JF - Cell

IS - 2

ER -

Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma

Abstract

Keywords

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