TY - JOUR
T1 - Insulin Resistance, Hyperinsulinemia, and Energy Intake in Overweight Children
AU - Han, Joan C.
AU - Rutledge, Margaret S.
AU - Kozlosky, Merel
AU - Salaita, Christine G.
AU - Gustafson, Jennifer K.
AU - Keil, Margaret F.
AU - Fleisch, Abby F.
AU - Roberts, Mary D.
AU - Ning, Cong
AU - Yanovski, Jack A.
N1 - Funding Information:
Supported by the Intramural Research Program of the NIH with the grant ZO1 HD-00641 (to JAY) from the National Institute of Child Health and Human Development and by a supplement from the National Center for Minority Health and Health Disparities (to JAY), National Institutes of Health. AFF was supported by the NIH Clinical Research Training Program, a public-private partnership funded jointly by the NIH and a grant to the Foundation for the NIH from Pfizer Pharmaceuticals Group. J.C.H., M.K., and J.A.Y. are Commissioned Officers in the United States Public Health Service, DHHS.
PY - 2008/5
Y1 - 2008/5
N2 - Objective: To examine the relationship between energy intake during a buffet meal and indexes of insulin dynamics in overweight children. Study design: Ninety-five nondiabetic, overweight (body mass index ≥95th percentile) children (age 10.3 ± 1.4 years) selected lunch from a 9835-kcal buffet eaten ad libitum after an overnight fast. The associations between energy intake and measures of insulin dynamics, in the postabsorptive state and during a 2-hour hyperglycemic clamp, were determined. Covariates in the statistical model included race, sex, skeletal age, fat-free mass, fat mass, socioeconomic status, and number of foods in the buffet rated as acceptable. Results: Energy intake was positively associated with the fasting homeostasis model assessment for insulin resistance index (β = 0.24, P = .042), fasting insulin/glucose ratio (β = 0.24, P = .044), first-phase insulin (β = 0.23, P = .032), and first-phase C-peptide (β = 0.21, P = .046); energy intake was negatively associated with clamp-derived insulin sensitivity (β = -0.29, P = .042). Each 10% decrease in clamp-derived insulin sensitivity predicted a 27-kcal greater energy intake. Conclusions: Insulin resistance and hyperinsulinemia are associated with greater energy intake after an overnight fast in overweight children. These associations suggest mechanisms whereby insulin resistance may contribute to excessive weight gain in children.
AB - Objective: To examine the relationship between energy intake during a buffet meal and indexes of insulin dynamics in overweight children. Study design: Ninety-five nondiabetic, overweight (body mass index ≥95th percentile) children (age 10.3 ± 1.4 years) selected lunch from a 9835-kcal buffet eaten ad libitum after an overnight fast. The associations between energy intake and measures of insulin dynamics, in the postabsorptive state and during a 2-hour hyperglycemic clamp, were determined. Covariates in the statistical model included race, sex, skeletal age, fat-free mass, fat mass, socioeconomic status, and number of foods in the buffet rated as acceptable. Results: Energy intake was positively associated with the fasting homeostasis model assessment for insulin resistance index (β = 0.24, P = .042), fasting insulin/glucose ratio (β = 0.24, P = .044), first-phase insulin (β = 0.23, P = .032), and first-phase C-peptide (β = 0.21, P = .046); energy intake was negatively associated with clamp-derived insulin sensitivity (β = -0.29, P = .042). Each 10% decrease in clamp-derived insulin sensitivity predicted a 27-kcal greater energy intake. Conclusions: Insulin resistance and hyperinsulinemia are associated with greater energy intake after an overnight fast in overweight children. These associations suggest mechanisms whereby insulin resistance may contribute to excessive weight gain in children.
UR - http://www.scopus.com/inward/record.url?scp=41849093665&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2007.12.036
DO - 10.1016/j.jpeds.2007.12.036
M3 - Article
C2 - 18410761
AN - SCOPUS:41849093665
SN - 0022-3476
VL - 152
SP - 612-617.e1
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 5
ER -