Insulin-like growth factors in health and disease

Derek LeRoith, David Clemmons, Peter Nissley, Matthew M. Rechler

Research output: Contribution to journalArticlepeer-review

151 Scopus citations


The insulin-like growth factor (IGF) family of peptides, binding proteins, and receptors are ubiquitous and important for normal human growth and development. Modern techniques including specific radioimmunoassays, radioreceptor assays and recombinant DNA technology have improved our understanding of the role of IGFs in growth and development. In addition to enhancing our understanding of normal physiology, these techniques assess changes in these hormones, binding proteins, and receptors in pathologic conditions including growth retardation, acromegaly, malnutrition, diabetes, and malignancy. Further, these studies have led to improvement in the assessment of responses to certain therapies used in the treatment of these diseases and may lead to improvements in these therapies.

Original languageEnglish
Pages (from-to)854-862
Number of pages9
JournalAnnals of Internal Medicine
Issue number10
StatePublished - May 1992
Externally publishedYes


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