TY - JOUR
T1 - Insulin-like Growth Factors and Diabetic Retinopathy
AU - Carroll, Patricia B.
AU - Kornbluth, Arthur
AU - Merimee, Thomas J.
PY - 1983/12/29
Y1 - 1983/12/29
N2 - To the Editor: The cautious hypothesis of Merimee et al. (Sept. 1 issue) that high levels of insulin-like growth factor (IGF) I contribute to or cause accelerated proliferation of new vessels is not warranted on the basis of their data.1 First of all, this was a cross-sectional analysis; patients were not studied prospectively to determine whether IGF levels could predict which patients were at high risk of proliferation. An association, if indeed there was one, is therefore weakened. Secondly, one would like to be given information on factors known to be associated with retinopathy, such as the duration of disease.
AB - To the Editor: The cautious hypothesis of Merimee et al. (Sept. 1 issue) that high levels of insulin-like growth factor (IGF) I contribute to or cause accelerated proliferation of new vessels is not warranted on the basis of their data.1 First of all, this was a cross-sectional analysis; patients were not studied prospectively to determine whether IGF levels could predict which patients were at high risk of proliferation. An association, if indeed there was one, is therefore weakened. Secondly, one would like to be given information on factors known to be associated with retinopathy, such as the duration of disease.
UR - http://www.scopus.com/inward/record.url?scp=0021115199&partnerID=8YFLogxK
U2 - 10.1056/NEJM198312293092614
DO - 10.1056/NEJM198312293092614
M3 - Letter
C2 - 6358893
AN - SCOPUS:0021115199
SN - 0028-4793
VL - 309
SP - 1649
EP - 1650
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 26
ER -