Insulin-like growth factors and cancer

Derek LeRoith, Renato Baserga, Lee Helman, Charles T. Roberts

Research output: Contribution to journalArticlepeer-review

303 Scopus citations


The insulin-like growth factor (IGF) family of peptides, binding proteins, and receptors are important for normal human growth and development and are involved in the specialized functions of most physiologic systems. Most members of the IGF system are expressed by different cancer cells and may play an important role in the propagation of these malignancies. New therapies aimed at modulating various components of the IGF system could affect the progression and metastasis of cancer.

Original languageEnglish
Pages (from-to)54-59
Number of pages6
JournalAnnals of Internal Medicine
Issue number1
StatePublished - 1 Jan 1995
Externally publishedYes


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