Insulin-like growth factors

Derek LeRoith; Carolyn Bondy

doi:10.1016/S1874-5687(96)80003-6

Insulin-like growth factors

Derek LeRoith, Carolyn Bondy

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

The insulin-like growth factor family of peptides, binding proteins and receptors is involved in normal growth and development. Later they are important in the differentiated function of a number of tissues. Aberrations in this growth factor system are associated with different diseases, ranging from short stature and diabetes to malignancy. With the advent of recombinant DNA technology, sufficient quantities of the ligands (and binding proteins) have become available for clinical testing in the therapy of certain diseases. These exciting new possibilities need to be assessed carefully for side-effects.

Original language	English
Pages (from-to)	1-26
Number of pages	26
Journal	Growth Factors and Cytokines in Health and Disease
Volume	1
Issue number	C
DOIs	https://doi.org/10.1016/S1874-5687(96)80003-6
State	Published - 1996
Externally published	Yes

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AB - The insulin-like growth factor family of peptides, binding proteins and receptors is involved in normal growth and development. Later they are important in the differentiated function of a number of tissues. Aberrations in this growth factor system are associated with different diseases, ranging from short stature and diabetes to malignancy. With the advent of recombinant DNA technology, sufficient quantities of the ligands (and binding proteins) have become available for clinical testing in the therapy of certain diseases. These exciting new possibilities need to be assessed carefully for side-effects.

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Insulin-like growth factors

Abstract

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