Insulin Delivery and Glucose Variability Throughout the Menstrual Cycle on Closed Loop Control for Women with Type 1 Diabetes

Carol J. Levy, Grenye O'Malley, Dan Raghinaru, Yogish C. Kudva, Lori M. Laffel, Jordan E. Pinsker, John W. Lum, Sue A. Brown

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objective: To analyze insulin delivery and glycemic metrics throughout the menstrual cycle for women with type 1 diabetes using closed loop control (CLC) insulin delivery. Methods: Menstruating women using a CLC system in a clinical trial were invited to record their menstrual cycles through a cycle-tracking application. Sixteen participants provided data for this secondary analysis over three or more complete cycles. Insulin delivery and continuous glucose monitoring (CGM) data were analyzed in relation to reported cycle phases. Results: Insulin delivery and CGM metrics remained consistent during cycle phases. Intraparticipant variability of CGM metrics and weight-based insulin delivery did not change through cycle phases. Conclusions: For this sample of menstruating women with type 1 diabetes using a CLC system, insulin delivery and glycemic metrics remained stable throughout menstrual cycle phases. Additional studies in this population are needed, particularly among women who report variable glycemic control during their cycles. Trial Registration: NCT03591354.

Original languageEnglish
Pages (from-to)357-361
Number of pages5
JournalDiabetes Technology and Therapeutics
Volume24
Issue number5
DOIs
StatePublished - May 2022
Externally publishedYes

Keywords

  • Closed loop control
  • Glucose variability
  • Menstrual cycle
  • Type 1 diabetes
  • adult
  • female

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