Insulin and insulin-like growth factor I receptors: Similarities and differences in signal transduction

Joelle Dupont, Derek LeRoith

Research output: Contribution to journalArticlepeer-review

171 Scopus citations

Abstract

The insulin receptor (IR) and the insulin-like growth factor I receptor (IGF-IR) belong to the same subfamily of receptor tyrosine kinases with two extracellular α-subunits and two transmembrane β-subunits. They share a high similarity of structure and intracellular signalling events. However, the IR and the IGF-IR mediate different effects on metabolism, cell proliferation, apoptosis and differentiation. Although some of the variation can be attributed to a different tissue distribution or subcellular localization, it can also be explained by structural differences in the β-subunit, which may result in activation of specific substrates and signal pathways.

Original languageEnglish
Pages (from-to)22-26
Number of pages5
JournalHormone Research
Volume55
Issue numberSUPPL. 2
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Insulin receptor
  • Insulin-like growth factor I receptor
  • Signal transduction
  • Signalling
  • Specificity

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