Abstract
Insulin and IGF-I binding to neuroblastoma cells (SK-N-MC) was increased by 13% and 7% respectively following a 24 hr. incubation with the sulphonylurea glyburide. This increase in binding was associated with increased steady-state levels of insulin receptor and IGF-I receptor mRNA levels. Though insulin and IGF-I both stimulate glucose uptake into these cells, the increased binding following glyburide treatment was not associated with any change in glucose uptake.
Original language | English |
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Pages (from-to) | 171-175 |
Number of pages | 5 |
Journal | Neuropeptides |
Volume | 14 |
Issue number | 3 |
DOIs | |
State | Published - Oct 1989 |
Externally published | Yes |