TY - JOUR
T1 - Insulin action in aging man
T2 - Evidence for tissue-specific differences at low physiologic insulin levels
AU - Meneilly, G. S.
AU - Minaker, K. L.
AU - Elahi, D.
AU - Rowe, J. W.
PY - 1987
Y1 - 1987
N2 - This study examined the effect of age on insulin action in several tissues. Euglycemic insulin clamp studies were performed on healthy young (n = 7, 20 to 35 years, 10 and 20 mU/m2·min insulin infusions) and old (n = 7, 66 to 80 years, 8 and 16 mU/m2·min insulin infusions) adults. Insulin values were similar during both the lower (young, 24 ± 1.6, old, 24 ± 2.1 μU/ml) and higher (young, 40 ± 3.3; old, 39 ± 3.8 μU/ml) insulin infusion rates. Although suppression of hepatic glucose output (HGO) was more rapid (p < .05) in the elderly group at each dose, HGO was eventually suppressed to similar levels in both age groups (low dose: young, 34.4 ± 10.8, old, 25.3 ± 1.8 mg/m2·min; higher dose: young, 22.8 ± 10.2, old, 6.2 ± 2.1 mg/m2·min). Glucose disposal was less (p < .01) in the aged group at both insulin infusion rates. Suppression of C-peptide was slower in the elderly participants (p < .05) in the low dose study. Suppression of free fatty acid and glucagon levels was the same in each age group. We concluded that the insulin resistance of aging is not generalized to all tissues.
AB - This study examined the effect of age on insulin action in several tissues. Euglycemic insulin clamp studies were performed on healthy young (n = 7, 20 to 35 years, 10 and 20 mU/m2·min insulin infusions) and old (n = 7, 66 to 80 years, 8 and 16 mU/m2·min insulin infusions) adults. Insulin values were similar during both the lower (young, 24 ± 1.6, old, 24 ± 2.1 μU/ml) and higher (young, 40 ± 3.3; old, 39 ± 3.8 μU/ml) insulin infusion rates. Although suppression of hepatic glucose output (HGO) was more rapid (p < .05) in the elderly group at each dose, HGO was eventually suppressed to similar levels in both age groups (low dose: young, 34.4 ± 10.8, old, 25.3 ± 1.8 mg/m2·min; higher dose: young, 22.8 ± 10.2, old, 6.2 ± 2.1 mg/m2·min). Glucose disposal was less (p < .01) in the aged group at both insulin infusion rates. Suppression of C-peptide was slower in the elderly participants (p < .05) in the low dose study. Suppression of free fatty acid and glucagon levels was the same in each age group. We concluded that the insulin resistance of aging is not generalized to all tissues.
UR - http://www.scopus.com/inward/record.url?scp=0023095290&partnerID=8YFLogxK
U2 - 10.1093/geronj/42.2.196
DO - 10.1093/geronj/42.2.196
M3 - Article
C2 - 3546473
AN - SCOPUS:0023095290
SN - 0022-1422
VL - 42
SP - 196
EP - 201
JO - Journals of Gerontology
JF - Journals of Gerontology
IS - 2
ER -