Instrumentation for Multi-modal Spectroscopic Diagnosis of Epithelial Dysplasia

James W. Tunnell; Adrien E. Desjardins; Luis Galindo; Irene Georgakoudi; Sasha A. McGee; Jelena Mirkovic; Markus G. Mueller; Jon Nazemi; Freddy T. Nguyen; Adam Wax; Qingguo Zhang; Ramachandra R. Dasari; Michael S. Feld

doi:10.1177/153303460300200603

Instrumentation for Multi-modal Spectroscopic Diagnosis of Epithelial Dysplasia

James W. Tunnell, Adrien E. Desjardins, Luis Galindo, Irene Georgakoudi, Sasha A. McGee, Jelena Mirkovic, Markus G. Mueller, Jon Nazemi, Freddy T. Nguyen, Adam Wax, Qingguo Zhang, Ramachandra R. Dasari, Michael S. Feld

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46 Scopus citations

Abstract

Reflectance and fluorescence spectroscopies have shown great promise for early detection of epithelial dysplasia. We have developed a clinical reflectance spectrofluorimeter for multimodal spectroscopic diagnosis of epithelial dysplasia. This clinical instrument, the FastEEM, collects white light reflectance and fluorescence excitation-emission matrices (EEM's) within a fraction of a second. In this paper we describe the FastEEM instrumentation, designed for collection of multi-modal spectroscopic data. We illustrate its performance using tissue phantoms with well defined optical properties and biochemicals of known fluorescence properties. In addition, we discuss our plans to develop a system that combines a multi-spectral imaging device for wide area surveillance with this contact probe device.

Original language	English
Pages (from-to)	505-514
Number of pages	10
Journal	Technology in Cancer Research and Treatment
Volume	2
Issue number	6
DOIs	https://doi.org/10.1177/153303460300200603
State	Published - Dec 2003
Externally published	Yes

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Tunnell, J. W., Desjardins, A. E., Galindo, L., Georgakoudi, I., McGee, S. A., Mirkovic, J., Mueller, M. G., Nazemi, J., Nguyen, F. T., Wax, A., Zhang, Q., Dasari, R. R., & Feld, M. S. (2003). Instrumentation for Multi-modal Spectroscopic Diagnosis of Epithelial Dysplasia. Technology in Cancer Research and Treatment, 2(6), 505-514. https://doi.org/10.1177/153303460300200603

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title = "Instrumentation for Multi-modal Spectroscopic Diagnosis of Epithelial Dysplasia",

abstract = "Reflectance and fluorescence spectroscopies have shown great promise for early detection of epithelial dysplasia. We have developed a clinical reflectance spectrofluorimeter for multimodal spectroscopic diagnosis of epithelial dysplasia. This clinical instrument, the FastEEM, collects white light reflectance and fluorescence excitation-emission matrices (EEM's) within a fraction of a second. In this paper we describe the FastEEM instrumentation, designed for collection of multi-modal spectroscopic data. We illustrate its performance using tissue phantoms with well defined optical properties and biochemicals of known fluorescence properties. In addition, we discuss our plans to develop a system that combines a multi-spectral imaging device for wide area surveillance with this contact probe device.",

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year = "2003",

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doi = "10.1177/153303460300200603",

language = "English",

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AU - Tunnell, James W.

AU - Desjardins, Adrien E.

AU - Galindo, Luis

AU - Georgakoudi, Irene

AU - McGee, Sasha A.

AU - Mirkovic, Jelena

AU - Mueller, Markus G.

AU - Nazemi, Jon

AU - Nguyen, Freddy T.

AU - Wax, Adam

AU - Zhang, Qingguo

AU - Dasari, Ramachandra R.

AU - Feld, Michael S.

PY - 2003/12

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AB - Reflectance and fluorescence spectroscopies have shown great promise for early detection of epithelial dysplasia. We have developed a clinical reflectance spectrofluorimeter for multimodal spectroscopic diagnosis of epithelial dysplasia. This clinical instrument, the FastEEM, collects white light reflectance and fluorescence excitation-emission matrices (EEM's) within a fraction of a second. In this paper we describe the FastEEM instrumentation, designed for collection of multi-modal spectroscopic data. We illustrate its performance using tissue phantoms with well defined optical properties and biochemicals of known fluorescence properties. In addition, we discuss our plans to develop a system that combines a multi-spectral imaging device for wide area surveillance with this contact probe device.

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Instrumentation for Multi-modal Spectroscopic Diagnosis of Epithelial Dysplasia

Abstract

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