@article{68fcb14e835945e4814b5dc766cffb18,
title = "Institutional profile: Translational pharmacogenomics at the Icahn School of Medicine at Mount Sinai",
abstract = "For almost 50 years, the Icahn School of Medicine at Mount Sinai has continually invested in genetics and genomics, facilitating a healthy ecosystem that provides widespread support for the ongoing programs in translational pharmacogenomics. These programs can be broadly cataloged into discovery, education, clinical implementation and testing, which are collaboratively accomplished by multiple departments, institutes, laboratories, companies and colleagues. Focus areas have included drug response association studies and allele discovery, multiethnic pharmacogenomics, personalized genotyping and survey-based education programs, pre-emptive clinical testing implementation and novel assay development. This overview summarizes the current state of translational pharmacogenomics at Mount Sinai, including a future outlook on the forthcoming expansions in overall support, research and clinical programs, genomic technology infrastructure and the participating faculty.",
keywords = "Icahn School of Medicine at Mount Sinai, clinical implementation, discovery, education, genetic testing, pharmacogenetics, pharmacogenomics",
author = "Scott, {Stuart A.} and {Owusu Obeng}, Aniwaa and Botton, {Mariana R.} and Yao Yang and Scott, {Erick R.} and Ellis, {Stephen B.} and Richard Wallsten and Tom Kaszemacher and Xiang Zhou and Rong Chen and Paola Nicoletti and Hetanshi Naik and Kenny, {Eimear E.} and Aida Vega and Eva Waite and Diaz, {George A.} and Joel Dudley and Halperin, {Jonathan L.} and Lisa Edelmann and Andrew Kasarskis and Hulot, {Jean S{\'e}bastien} and Inga Peter and Bottinger, {Erwin P.} and Kurt Hirschhorn and Pamela Sklar and Cho, {Judy H.} and Desnick, {Robert J.} and Schadt, {Eric E.}",
note = "Funding Information: This work was supported in part by the National Institute of General Medical Sciences (NIGMS) of the NIH through grant K23GM104401 (SA Scott), and the National Human Genome Research Institute (NHGRI) of the NIH through grants U01HG008701-02S1 and U01HG006380 (eMERGE Network; EP Bottinger, AO Obeng) and U01HG007278 (IGNITE Network; EP Bottinger, AO Obeng). Funding for The Charles Bronfman Institute for Personalized Medicine was provided by the Andrea and Charles Bronfman Philanthropies and the Icahn School of Medicine at Mount Sinai. SA Scott, MR Botton, Y Yang, ER Scott, R Wallsten, X Zhou, R Chen, P Nicoletti, GA Diaz, L Edelmann, RJ Desnick and EE Schadt are paid employees or consultants of Sema4, which is a commercial company that offers clinical pharmacogenomic testing. EP Bottinger and SB Ellis are named co-inventors on a patent application and have developed software and know-how related to CLIPMERGE, a medical decision support software platform that collects, aggregates and displays clinical data. The platform allows for personalized medical decision making. The CLIPMERGE tool is being utilized in pharmacogenetics research described in this manuscript. The intellectual property related to the software and know-how has been licensed by the Icahn School of Medicine to Ontomics Inc, a privately held company in which EP Bottinger and SB Ellis are equity owners. If the CLIPMERGE technology is commercially successful, EP Bottinger and SB Ellis will benefit financially and, in addition, payments will be made to the Icahn School of Medicine as part of the license agreement. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2017 Future Medicine Ltd.",
year = "2017",
month = oct,
doi = "10.2217/pgs-2017-0137",
language = "English",
volume = "18",
pages = "1381--1386",
journal = "Pharmacogenomics",
issn = "1462-2416",
publisher = "Future Medicine Ltd.",
number = "15",
}