Insights into the ageing mind: A view from cognitive neuroscience

Trey Hedden, John D.E. Gabrieli

Research output: Contribution to journalReview articlepeer-review

1683 Scopus citations


As we grow older, we may grow wiser, but we can also experience memory loss and cognitive slowing that can interfere with our daily routines. The cognitive neuroscience of human ageing, which relies largely on neuroimaging techniques, relates these cognitive changes to their neural substrates, including structural and functional changes in the prefrontal cortex, medial temporal lobe regions and white matter tracts. Much remains unknown about how normal ageing affects the neural basis of cognition, but recent research on individual differences in the trajectory of ageing effects is helping to distinguish normal from pathological origins of age-related cognitive changes.

Original languageEnglish
Pages (from-to)87-96
Number of pages10
JournalNature Reviews Neuroscience
Issue number2
StatePublished - Feb 2004
Externally publishedYes


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