Insider access: Pepducin symposium explores a new approach to GPCR modulation

Jacquelyn Miller, Anika Agarwal, Lakshmi A. Devi, Kellen Fontanini, James A. Hamilton, Jean Philippe Pin, Denis C. Shields, C. Arnold Spek, Thomas P. Sakmar, Athan Kuliopulos, Stephen W. Hunt

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

The inaugural Pepducin Science Symposium convened in Cambridge, Massachusetts on March 8-9, 2009 provided the opportunity for an international group of distinguished scientists to present and discuss research regarding G protein-coupled receptor-related research. G protein-coupled receptors (GPCRs) are, arguably, one of the most important molecular targets in drug discovery and pharmaceutical development today. This superfamily of membrane receptors is central to nearly every signaling pathway in the human body and has been the focus of intense research for decades. However, as scientists discover additional properties of GPCRs, it has become clear that much is yet to be understood about how these receptors function. Everyone agrees, however, that tremendous potential remains if specific GPCR signaling pathways can be modulated to correct pathological states. One exciting new approach to this challenge involves pepducins: novel, synthetic lipopeptide pharmacophores that modulate heptahelical GPCR activity from inside the cell membrane.

Original languageEnglish
Pages (from-to)E1-E12
JournalAnnals of the New York Academy of Sciences
Volume1180
Issue numberSUPPL. 1
DOIs
StatePublished - Nov 2009

Keywords

  • G protein-coupled receptors
  • meeting report
  • pepducins
  • transmembrane signaling

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