Innovative vaccine approaches—a Keystone Symposia report

Jennifer Cable, Rino Rappuoli, Elizabeth J. Klemm, Gagandeep Kang, Ankur Mutreja, Gavin J. Wright, Mariagrazia Pizza, Sowmya Ajay Castro, Joseph P. Hoffmann, Galit Alter, Andrea Carfi, Andrew J. Pollard, Florian Krammer, Ravindra K. Gupta, Caroline E. Wagner, Viviane Machado, Kayvon Modjarrad, Lawrence Corey, Peter B. Gilbert, Gordon DouganNicole Lurie, Pamela J. Bjorkman, Christopher Chiu, Elisa Nemes, Stephen B. Gordon, Andrew C. Steer, Thomas Rudel, Catherine A. Blish, John Tyler Sandberg, Kiva Brennan, Keith P. Klugman, Lynda M. Stuart, Shabir A. Madhi, Christopher L. Karp

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The rapid development of COVID-19 vaccines was the result of decades of research to establish flexible vaccine platforms and understand pathogens with pandemic potential, as well as several novel changes to the vaccine discovery and development processes that partnered industry and governments. And while vaccines offer the potential to drastically improve global health, low-and-middle-income countries around the world often experience reduced access to vaccines and reduced vaccine efficacy. Addressing these issues will require novel vaccine approaches and platforms, deeper insight how vaccines mediate protection, and innovative trial designs and models. On June 28–30, 2021, experts in vaccine research, development, manufacturing, and deployment met virtually for the Keystone eSymposium “Innovative Vaccine Approaches” to discuss advances in vaccine research and development.

Original languageEnglish
Pages (from-to)59-86
Number of pages28
JournalAnnals of the New York Academy of Sciences
Issue number1
StatePublished - May 2022


  • COVID-19
  • correlates of protection
  • human challenge studies
  • influenza
  • pneumococcal disease
  • streptococcus
  • vaccine equity
  • vaccines


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