Innate response activator B cells: Origins and functions

Benjamin G. Chousterman, Filip K. Swirski

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Innate response activator (IRA) B cells are a subset of B-1a derived B cells that produce the growth factors granulocyte macrophage colony stimulating factor and IL-3. In mouse models of sepsis and pneumonia, B-1a B cells residing in serosal sites recognize bacteria, migrate to the spleen or lung, and differentiate to IRA B cells that then contribute to the host response by amplifying inflammation and producing polyreactive IgM. In atherosclerosis, IRA B cells accumulate in the spleen, where they promote extramedullary hematopoiesis and activate classical dendritic cells. In this review, we focus on the ontogeny and function of IRA B cells in acute and chronic inflammation.

Original languageEnglish
Pages (from-to)537-541
Number of pages5
JournalInternational Immunology
Volume27
Issue number10
DOIs
StatePublished - Oct 2015
Externally publishedYes

Keywords

  • B1a cells
  • GM-CSF
  • IL-3
  • IRA B cells
  • IgM
  • innate immunity

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