Innate immunity: Actuating the gears of celiac disease pathogenesis

Sangman Michael Kim, Toufic Mayassi, Bana Jabri

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations

Abstract

Celiac disease is a T cell mediated immune disorder characterized by the loss of oral tolerance to dietary gluten and the licensing of intraepithelial lymphocytes to kill intestinal epithelial cells, leading to villous atrophy. Innate immunity plays a critical role in both of these processes and cytokines such as interleukin-15 and interferon-α can modulate innate processes such as polarization of dendritic cells as well as intraepithelial lymphocyte function. These cytokines can be modulated by host microbiota, which can also influence dendritic cell function and intraepithelial lymphocyte homeostasis. We will elaborate on the role of interleukin-15, interferon-α, and the microbiota in modulating the processes that lead to loss of tolerance to gluten and tissue destruction in celiac disease.

Original languageEnglish
Pages (from-to)425-435
Number of pages11
JournalBest Practice and Research: Clinical Gastroenterology
Volume29
Issue number3
DOIs
StatePublished - 2015
Externally publishedYes

Keywords

  • Celiac disease
  • Dysbiosis
  • Immune tolerance
  • Innate immunity
  • Interferons
  • Interleukin-15
  • Microbiota

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