@article{a3366d9870074c24a57399fe99823f33,
title = "Injuries in adolescents with childhood-onset epilepsy compared with sibling controls",
abstract = "Objective To compare the occurrence of injuries in adolescents with childhood-onset epilepsy and matched sibling controls. Study design Retrospective case-control lifetime injury assessments were obtained from a community-based cohort of adolescents with childhood-onset epilepsy diagnosed 9 years earlier and their siblings. The children with epilepsy (n = 501; mean age, 15.3 years) included those with complicated (abnormal neurologic examination or IQ <80; n = 133) and uncomplicated (normal neurologic examination and IQ ≥80; n = 368) epilepsy. Children with uncomplicated epilepsy were matched to sibling controls (n = 210 pairs). The children reported whether or not they had ever (before and after epilepsy diagnosis) experienced injuries {"}serious enough to require medical attention{"} and if so, the type of treatment required. Results Almost one-half (49.1%) of the children with epilepsy experienced injury, of whom 8.9% required surgery/hospitalization and 17.1% had injury related to a seizure. Fewer children with uncomplicated epilepsy had seizure-related injuries versus those with complicated epilepsy (13.6% vs 27.4%; P ≤.01). The proportion of children with epilepsy with any injury by type (not mutually exclusive) were: 25.2% with fractures (n = 126); 24.4% with head injuries (n = 122); 10.2% with other injuries (n = 51); 8.4% with dental injuries (n = 42); and 8% with burns/scalds (n = 40). A similar proportion of children with uncomplicated epilepsy experienced any injury (overall and by type) compared to matched sibling controls, with the exception that more children with uncomplicated epilepsy had head injuries (30.0% vs 19.5%; P <.02). Conclusion With the exception of head injuries, we found no evidence of an increased risk of injury in a representative cohort of children with epilepsy compared with matched sibling controls. This finding may reflect the fact that the sample was not biased to more severe cases, or that safety precautions to prevent injury were widely used.",
author = "Baca, {Christine B.} and Vickrey, {Barbara G.} and Vassar, {Stefanie D.} and Aaron Cook and Berg, {Anne T.}",
note = "Funding Information: B.V. serves on scientific advisory boards for the Sports Concussion Institute, American Heart Association, and the National Institutes of Health (NIH); serves on the editorial board of Neurorehabilitation and Neural Repair; is a Section Editor for Stroke; receives research support from the NIH (National Institute of Aging – RC4AG038804 and 1U54 NS081764), the US Veterans Administration Health Services Research and Development Service (Nursing Research Initiative-11-126 and Veterans Administration Quality Enhancement Research Initiative Platelet-Rich Plasma), the American Heart Association (American Heart Association/Pharmaceutical Roundtable 0875133N), and the Food and Drug Administration (R01 FD003923); is a consultant to EMD Serono Canada and to Imperial Clinical Research Services, Inc; and has received travel support from the National Parkinson Foundation and Cure Huntington's Disease Initiative. S.V. receives support from National Institute of Neurological Diseases and Stroke-1U54 NS081764 and National Center for Advancing Translational Science-UL1TR000124. A.B. has received travel funding and honoraria from Eisai, the British Pediatric Neurological Association, and the Epilepsy Research Center (Melbourne); travel funding from UCB, the American Epilepsy Society, and the International League Against Epilepsy, and BIAL; awards from the American Epilepsy Society and British Pediatric Neurological Association; consulting fees from Dow Agro Science; serves on the Editorial Boards of Epileptic Disorders, Epilepsy & Behavior, and Neurology; and is past Chair of the International League Against Epilepsy's Commission on Classification and Terminology, and Steward for the National Institute of Neurological Diseases and Stroke Benchmarks in Epilepsy Research. The other authors declare no conflicts of interest. Funding Information: Funded by the National Institutes of Health ( National Institute of Neurological Disorders and Stroke [ NINDS ] R37-NS31146 [PI: A.B.]). All authors funded by NINDS ( R37-NS31146 ). The study sponsor did not have a role in study design, collection, analysis, interpretation of data, writing of the report, or decision to submit the manuscript. Conflict of interest information is available at www.jpeds.com ( Appendix ). ",
year = "2013",
month = dec,
doi = "10.1016/j.jpeds.2013.07.046",
language = "English",
volume = "163",
pages = "1684--1691.e4",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "6",
}