TY - GEN
T1 - Injectable sulfonated methylcellulose hydrogels for growth factor sequestration and nucleus pulposus repair
AU - Haq-Siddiqi, Nada A.
AU - Bunde, Katie
AU - Nnadi, Wilson O.
AU - Iatridis, James C.
AU - Nicoll, Steven B.
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
PY - 2019
Y1 - 2019
N2 - Intervertebral disc (IVD) degeneration and injury is a major cause of lower back pain, often necessitating surgical intervention.1 Removal of the nucleus pulposus (NP) is a common intervention, but can result in altered mechanics and further degradation long term. Various materials are under investigation for use as NP replacements. Methylcellulose (MC) is a low-cost, biocompatible polysaccharide with intrinsic thermogelling properties that has been explored for IVD repair.2 Ideally, such scaffolds should incorporate growth factors and retain them within the construct to direct cell differentiation and tissue healing. Sulfation has been used to electrostatically sequester soluble proteins in biomaterials.3,4 Moreover, matrix sulfation is critical for the development of healthy skeletal tissues and may enhance regenerative therapies.5 Therefore, the aim of this study was to engineer sulfonated MC (sMC) scaffolds and investigate their interaction with proteins and potential for NP tissue replacement.
AB - Intervertebral disc (IVD) degeneration and injury is a major cause of lower back pain, often necessitating surgical intervention.1 Removal of the nucleus pulposus (NP) is a common intervention, but can result in altered mechanics and further degradation long term. Various materials are under investigation for use as NP replacements. Methylcellulose (MC) is a low-cost, biocompatible polysaccharide with intrinsic thermogelling properties that has been explored for IVD repair.2 Ideally, such scaffolds should incorporate growth factors and retain them within the construct to direct cell differentiation and tissue healing. Sulfation has been used to electrostatically sequester soluble proteins in biomaterials.3,4 Moreover, matrix sulfation is critical for the development of healthy skeletal tissues and may enhance regenerative therapies.5 Therefore, the aim of this study was to engineer sulfonated MC (sMC) scaffolds and investigate their interaction with proteins and potential for NP tissue replacement.
UR - http://www.scopus.com/inward/record.url?scp=85065402014&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85065402014
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 10
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -