Inhibitory effects of human leukocyte and fibroblasts interferons on normal and chronic myelogenous leukemic granulocytic progenitor cells

Inhibitory effects of two human interferon preparations, leukocyte interferon (Le-IF) and fibroblast interferon (F-IF), on granulocytic progenitor cells (CFU-C) from hematologically normal cancer patients and from patients with chronic myelogenous leukemmia were evaluated. There was a wide variation in sensitivity of CFU-C to both Le-IF and F-IF. F-IF was more inhibitory against CFI-C than Le-IF. Normal CFU-C and chronic myelogenous Leukemia CFC-C were equally inhibited by both interferons. Effects of both interferons were neutralized by corresponding specific antisera but not by the other antisera. These observations confirmed that differences in immunogenicity of the interferons may attend their different origins.