Inhibition of the G2 DNA damage checkpoint by oliveroline isolated from Duguetia odorata

Harry C. Brastianos; Christopher M. Sturgeon; Michel Roberge; Raymond J. Andersen

doi:10.1021/np060285e

Inhibition of the G₂ DNA damage checkpoint by oliveroline isolated from Duguetia odorata

Harry C. Brastianos, Christopher M. Sturgeon, Michel Roberge, Raymond J. Andersen

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Plant extracts obtained from the U.S. National Cancer Institute's Open Repository collection have been screened for their ability to inhibit the G ₂ DNA damage checkpoint. An extract of Duguetia odorata showed promising activity in the assay. Bioassay-guided fractionation revealed that oliveroline (1) was responsible for the G₂ checkpoint inhibitory activity of the D. odorata extract. The new alkaloid JV-methylguatterine (2) was identified during this investigation.

Original language	English
Pages (from-to)	287-288
Number of pages	2
Journal	Journal of Natural Products
Volume	70
Issue number	2
DOIs	https://doi.org/10.1021/np060285e
State	Published - Feb 2007
Externally published	Yes

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10.1021/np060285e

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abstract = "Plant extracts obtained from the U.S. National Cancer Institute's Open Repository collection have been screened for their ability to inhibit the G 2 DNA damage checkpoint. An extract of Duguetia odorata showed promising activity in the assay. Bioassay-guided fractionation revealed that oliveroline (1) was responsible for the G2 checkpoint inhibitory activity of the D. odorata extract. The new alkaloid JV-methylguatterine (2) was identified during this investigation.",

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AU - Andersen, Raymond J.

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Inhibition of the G2 DNA damage checkpoint by oliveroline isolated from Duguetia odorata

Abstract

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Inhibition of the G₂ DNA damage checkpoint by oliveroline isolated from Duguetia odorata