Inhibition of the activin receptor Type-2B pathway restores regenerative capacity in satellite cell-depleted skeletal muscle

Luigi Formicola, Alice Pannérec, Rosa Maria Correra, Barbara Gayraud-Morel, David Ollitrault, Vanessa Besson, Shahragim Tajbakhsh, Jennifer Lachey, Jasbir S. Seehra, Giovanna Marazzi, David A. Sassoon

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Degenerative myopathies typically display a decline in satellite cells coupled with a replacement of muscle fibers by fat and fibrosis. During this pathological remodeling, satellite cells are present at lower numbers and do not display a proper regenerative function. Whether a decline in satellite cells directly contributes to disease progression or is a secondary result is unknown. In order to dissect these processes, we used a genetic model to reduce the satellite cell population by ~70-80% which leads to a nearly complete loss of regenerative potential. We observe that while no overt tissue damage is observed following satellite cell depletion, muscle fibers atrophy accompanied by changes in the stem cell niche cellular composition. Treatment of these mice with an Activin receptor type-2B (AcvR2B) pathway blocker reverses muscle fiber atrophy as expected, but also restores regenerative potential of the remaining satellite cells. These findings demonstrate that in addition to controlling fiber size, the AcvR2B pathway acts to regulate the muscle stem cell niche providing a more favorable environment for muscle regeneration.

Original languageEnglish
Article number515
JournalFrontiers in Physiology
Volume9
Issue numberMAY
DOIs
StatePublished - 24 May 2018
Externally publishedYes

Keywords

  • Muscle atrophy
  • Muscle regeneration
  • Muscle stem cell niche
  • Satellite cells
  • TGFβ signaling

Fingerprint

Dive into the research topics of 'Inhibition of the activin receptor Type-2B pathway restores regenerative capacity in satellite cell-depleted skeletal muscle'. Together they form a unique fingerprint.

Cite this