Inhibition of Rev activity and human immunodeficiency virus type 1 replication by antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element

G. Li, J. Lisziewicz, D. Sun, G. Zon, S. Daefler, F. Wong-Staal, R. C. Gallo, M. E. Klotman

Research output: Contribution to journalComment/debate

35 Scopus citations

Abstract

The interaction between the Rev protein of human immunodeficiency virus type 1 and its highly structured and conserved RNA target, the Rev-responsive element, is required for virus replication. We demonstrate that antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev- responsive element effectively inhibit Rev activity, as well as human immunodeficiency virus type 1 replication, and are candidates for antiviral therapy.

Original languageEnglish
Pages (from-to)6882-6888
Number of pages7
JournalJournal of Virology
Volume67
Issue number11
DOIs
StatePublished - 1993
Externally publishedYes

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