Abstract
The interaction between the Rev protein of human immunodeficiency virus type 1 and its highly structured and conserved RNA target, the Rev-responsive element, is required for virus replication. We demonstrate that antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element effectively inhibit Rev activity, as well as human immunodeficiency virus type 1 replication, and are candidates for antiviral therapy.
Original language | English |
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Pages (from-to) | 6882-6888 |
Number of pages | 7 |
Journal | Journal of Virology |
Volume | 67 |
Issue number | 11 |
State | Published - Nov 1993 |
Externally published | Yes |