Inhibition of rev activity and human immunodeficiency virus type 1 replication by antisense oligodeoxynucleotide phosphorothioate analogs directed against the rev-responsive element

G. E. Li; Julianna Lisziewicz; Daisy Sun; Gerald Zon; Simon Daefler; Flossie Wong-Staal; Robert C. Gallo; Mary E. Klotman

Inhibition of rev activity and human immunodeficiency virus type 1 replication by antisense oligodeoxynucleotide phosphorothioate analogs directed against the rev-responsive element

G. E. Li, Julianna Lisziewicz, Daisy Sun, Gerald Zon, Simon Daefler, Flossie Wong-Staal, Robert C. Gallo, Mary E. Klotman

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

The interaction between the Rev protein of human immunodeficiency virus type 1 and its highly structured and conserved RNA target, the Rev-responsive element, is required for virus replication. We demonstrate that antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element effectively inhibit Rev activity, as well as human immunodeficiency virus type 1 replication, and are candidates for antiviral therapy.

Original language	English
Pages (from-to)	6882-6888
Number of pages	7
Journal	Journal of Virology
Volume	67
Issue number	11
State	Published - Nov 1993
Externally published	Yes

Cite this

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abstract = "The interaction between the Rev protein of human immunodeficiency virus type 1 and its highly structured and conserved RNA target, the Rev-responsive element, is required for virus replication. We demonstrate that antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element effectively inhibit Rev activity, as well as human immunodeficiency virus type 1 replication, and are candidates for antiviral therapy.",

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AU - Li, G. E.

AU - Lisziewicz, Julianna

AU - Sun, Daisy

AU - Zon, Gerald

AU - Daefler, Simon

AU - Wong-Staal, Flossie

AU - Gallo, Robert C.

AU - Klotman, Mary E.

PY - 1993/11

Y1 - 1993/11

N2 - The interaction between the Rev protein of human immunodeficiency virus type 1 and its highly structured and conserved RNA target, the Rev-responsive element, is required for virus replication. We demonstrate that antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element effectively inhibit Rev activity, as well as human immunodeficiency virus type 1 replication, and are candidates for antiviral therapy.

AB - The interaction between the Rev protein of human immunodeficiency virus type 1 and its highly structured and conserved RNA target, the Rev-responsive element, is required for virus replication. We demonstrate that antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element effectively inhibit Rev activity, as well as human immunodeficiency virus type 1 replication, and are candidates for antiviral therapy.

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JF - Journal of Virology

IS - 11

ER -

Inhibition of rev activity and human immunodeficiency virus type 1 replication by antisense oligodeoxynucleotide phosphorothioate analogs directed against the rev-responsive element

Abstract

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