Inhibition of rev activity and human immunodeficiency virus type 1 replication by antisense oligodeoxynucleotide phosphorothioate analogs directed against the rev-responsive element

G. E. Li, Julianna Lisziewicz, Daisy Sun, Gerald Zon, Simon Daefler, Flossie Wong-Staal, Robert C. Gallo, Mary E. Klotman

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

The interaction between the Rev protein of human immunodeficiency virus type 1 and its highly structured and conserved RNA target, the Rev-responsive element, is required for virus replication. We demonstrate that antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element effectively inhibit Rev activity, as well as human immunodeficiency virus type 1 replication, and are candidates for antiviral therapy.

Original languageEnglish
Pages (from-to)6882-6888
Number of pages7
JournalJournal of Virology
Volume67
Issue number11
StatePublished - Nov 1993
Externally publishedYes

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