Inhibition of neuraminidase with neuraminic acid C-glycosides

Qun Wang; Michael Wolff; Tülay Polat; Yuguo Du; Robert J. Linhardt

doi:10.1016/S0960-894X(00)00132-3

Inhibition of neuraminidase with neuraminic acid C-glycosides

Qun Wang, Michael Wolff, Tülay Polat, Yuguo Du, Robert J. Linhardt

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Neuraminic (sialic) acid based α-C-glycosides have been synthesized and their inhibitory activity towards bacterial neuraminidase (sialidase) was examined. While some C-glycosides were found to be potent inhibitors (K(i) 15-30 μM) of this neuraminidase, others afforded no measurable activity. The structure-activity relationship of these C-glycosides is discussed in the context of other previously reported sialidase inhibitors. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	941-944
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	9
DOIs	https://doi.org/10.1016/S0960-894X(00)00132-3
State	Published - 1 May 2000
Externally published	Yes

Access to Document

10.1016/S0960-894X(00)00132-3

Cite this

@article{9534af998fe9458f8cccce52f065eab4,

title = "Inhibition of neuraminidase with neuraminic acid C-glycosides",

abstract = "Neuraminic (sialic) acid based α-C-glycosides have been synthesized and their inhibitory activity towards bacterial neuraminidase (sialidase) was examined. While some C-glycosides were found to be potent inhibitors (K(i) 15-30 μM) of this neuraminidase, others afforded no measurable activity. The structure-activity relationship of these C-glycosides is discussed in the context of other previously reported sialidase inhibitors. (C) 2000 Elsevier Science Ltd. All rights reserved.",

author = "Qun Wang and Michael Wolff and T{\"u}lay Polat and Yuguo Du and Linhardt, {Robert J.}",

year = "2000",

month = may,

day = "1",

doi = "10.1016/S0960-894X(00)00132-3",

language = "English",

volume = "10",

pages = "941--944",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "9",

}

TY - JOUR

T1 - Inhibition of neuraminidase with neuraminic acid C-glycosides

AU - Wang, Qun

AU - Wolff, Michael

AU - Polat, Tülay

AU - Du, Yuguo

AU - Linhardt, Robert J.

PY - 2000/5/1

Y1 - 2000/5/1

N2 - Neuraminic (sialic) acid based α-C-glycosides have been synthesized and their inhibitory activity towards bacterial neuraminidase (sialidase) was examined. While some C-glycosides were found to be potent inhibitors (K(i) 15-30 μM) of this neuraminidase, others afforded no measurable activity. The structure-activity relationship of these C-glycosides is discussed in the context of other previously reported sialidase inhibitors. (C) 2000 Elsevier Science Ltd. All rights reserved.

AB - Neuraminic (sialic) acid based α-C-glycosides have been synthesized and their inhibitory activity towards bacterial neuraminidase (sialidase) was examined. While some C-glycosides were found to be potent inhibitors (K(i) 15-30 μM) of this neuraminidase, others afforded no measurable activity. The structure-activity relationship of these C-glycosides is discussed in the context of other previously reported sialidase inhibitors. (C) 2000 Elsevier Science Ltd. All rights reserved.

UR - http://www.scopus.com/inward/record.url?scp=0034192455&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(00)00132-3

DO - 10.1016/S0960-894X(00)00132-3

M3 - Article

C2 - 10853664

AN - SCOPUS:0034192455

SN - 0960-894X

VL - 10

SP - 941

EP - 944

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 9

ER -

Inhibition of neuraminidase with neuraminic acid C-glycosides

Abstract

Access to Document

Fingerprint

Cite this