Inhibition of forskolin-stimulated adenylate cyclase activity by 5-HT receptor agonists

Michael Devivo, Saul Maayani

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

We measured the inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig hippocampal membranes by 5-HT, 5-carboxamidotryptamine (CAT) and 8-hydroxy-2-(di-n-propylamino) ttetralin (PAT). Low concentrations of these agonists inhibited forskolin-stimulated adenylate cyclase activity in a concentration-dependent and saturable manner. The antagonist spiperone shifted the concentration-response curve to CAT to the right in a parallel manner. The EC50 values of CAT, PAT and 5-HT and the KB of spiperone suggest that this receptor may correspond to the 5-HT1A binding site.

Original languageEnglish
Pages (from-to)231-234
Number of pages4
JournalEuropean Journal of Pharmacology
Volume119
Issue number3
DOIs
StatePublished - 17 Dec 1985
Externally publishedYes

Keywords

  • 5-HT
  • 5-Hydroxytryptamine
  • 8-Hydroxy-2-(di-n-propylamino) tetralin
  • Forskolin
  • Guinea pig
  • Hippocampal membranes
  • Inhibition of stimulated adenylate cyclase

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