Inhibition of fertility in the male mouse by combined androgen-antiandrogen therapy

D. Jacob, A. Narula

Research output: Contribution to journalArticlepeer-review

Abstract

Testosterone enanthate (TE) and oestradiol valerate (EV) in varying dose combinations were subcutaneously injected every alternate day for 10 or 20 days to adult male mouse of proven fertility. Such therapy resulted in suppression of fertility without affecting libido. The main possible cause of fertility inhibition appears to be testicular dysfunction as evidenced by histology and biochemistry of the reproductive organs.

Original languageEnglish
Pages (from-to)215-217
Number of pages3
JournalActa Europaea Fertilitatis
Volume22
Issue number4
StatePublished - 1991
Externally publishedYes

Keywords

  • androgen-antiandrogen
  • libido
  • male fertility
  • mouse
  • testicular inhibition

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