Abstract
The effect of zidovudine (3'-azido-3'-deoxythymidine; AZT) was investigated in four breast cancer cell lines, a T4 cell leukemia, and a normal breast cell line in vitro. AZT inhibited the growth of all tumoral cell lines, but it did so in a wide range of concentrations. The growth of a normal breast cell line was also inhibited, although it required a much higher concentration. Furthermore, AZT inhibited colony formation in soft agar and telomerase activity. These results indicated that AZT can be potentially used, alone or in combination, as an anti-breast cancer agent.
| Original language | English |
|---|---|
| Pages (from-to) | 693-696 |
| Number of pages | 4 |
| Journal | Clinical Cancer Research |
| Volume | 4 |
| Issue number | 3 |
| State | Published - Mar 1998 |