Inhibition of CD4+ T cell function by the HIV envelope protein, gp120

D. C. Diamond, B. P. Sleckman, T. Gregory, L. A. Lasky, J. L. Greenstein, S. J. Burakoff

Research output: Contribution to journalArticlepeer-review

128 Scopus citations


The CD4 molecule is functionally involved in the class II MHC-restricted T cell response to Ag. CD4 is also the receptor for HIV-1, the major etiologic agent of AIDS. We have assessed whether the interaction of the HIV-1 envelope protein with the CD4 molecule might interfere with the normal function of CD4, thereby contributing to the immunosuppression observed after HIV infection. Using a murine T cell hybridoma which expresses the human CD4 protein and exhibits a CD4-dependent response to Ag, we demonstrate that the HIV envelope protein gp120 can specifically inhibit this response.

Original languageEnglish
Pages (from-to)3715-3717
Number of pages3
JournalJournal of Immunology
Issue number11
StatePublished - 1988
Externally publishedYes


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