Inhibition of Acanthamoeba species by Pseudomonas aeruginosa: Rationale for their selective exclusion in corneal ulcers and contact lens care systems

M. N. Qureshi, A. A. Perez, R. M. Madayag, E. J. Bottone

Research output: Contribution to journalComment/debate

36 Scopus citations

Abstract

Cocultivation of Acanthamoeba castellani and Acanthamoeba polyphaga with live Pseudomonas aeruginosa and with broth filtrates of P. aeruginosa proved equally lethal to the Acanthamoeba spp. The P. aeruginosa-induced amebicidal activity is apparently toxin mediated and has two operative modes: it can function through binding of P. aeruginosa to the ameba membrane and in the presence of one or more P. aeruginosa exoproducts.

Original languageEnglish
Pages (from-to)1908-1910
Number of pages3
JournalJournal of Clinical Microbiology
Volume31
Issue number7
DOIs
StatePublished - 1993
Externally publishedYes

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