Infusion of donor leukocytes to induce tolerance in organ allograft recipients

S. K. Salgar, R. Shapiro, F. Dodson, R. Corry, K. McCurry, A. Zeevi, S. Pham, K. Abu-Elmagd, J. Reyes, M. Jordan, R. Keenan, B. Griffith, T. Sesky, L. Ostrowski, T. E. Starzl, J. J. Fung, Abdul S. Rao

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38 Scopus citations

Abstract

To further enhance chimerism, 229 primary allograft recipients have received perioperative intravenous infusion of a single dose of 3 to 6 x 108 unmodified donor bone marrow (BM) cells/kg body weight. In addition, 42 patients have been accrued in a concurrent protocol involving multiple (up to three) sequential perioperative infusions of 2 x 108 BM cells/kg/day from day 0-2 posttransplantation (PTx). Organ recipients (n = 133) for whom BM was not available were monitored as controls. The infusion of BM was safe and except for 50 (18%), all study patients have optimal graft function. Of the control patients, allografts in 30 (23%) have been lost during the course of follow-up. The cumulative risk of acute cellular rejection (ACR) was statistically lower in the study patients compared with that of controls. It is interesting that, 62% of BM-augmented heart recipients were free of ACR (Grade ≥ 3A) in the first 6 months PTx compared to controls. The incidence of obliterative bronchiolitis was also statistically lower in study lung recipients (3.8%) compared with the contemporaneously acquired controls (31%). The levels of donor cell chimerism were at least a log higher in the peripheral blood of majority of the study patients compared with that of controls. The incidence of donor-specific hyporeactivity, as determined by one-way mixed leukocyte reaction, was also higher in those BM-augmented liver, kidney, and lung recipients that could be evaluated compared to controls.

Original languageEnglish
Pages (from-to)310-314
Number of pages5
JournalJournal of Leukocyte Biology
Volume66
Issue number2
DOIs
StatePublished - 1999
Externally publishedYes

Keywords

  • Chimerism
  • Human
  • Transplantation

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