TY - CHAP
T1 - Influenza virus
T2 - The biology of a changing virus
AU - Mubareka, Samira
AU - Palese, Peter
PY - 2011
Y1 - 2011
N2 - Influenza viruses are members of the family Orthomyxoviridae and include influenza virus types A, B, and C. This introduction provides an overview of influenza virus classification, structure, and life cycle. We also include a brief review of the clinical manifestations of influenza and the molecular determinants for virulence. The genetic diversity of influenza A viruses and their capability to successfully infect an array of hosts, including avian and mammalian species, are highlighted in a discussion about host range and evolution. The importance of viral receptor-binding hemagglutinins and host sialic acid distribution in speciesrestricted binding of viruses is underscored. Finally, recent advances in our understanding of the seasonality and transmission of influenza viruses are described, and their importance for the control of the spread of these viruses is discussed.
AB - Influenza viruses are members of the family Orthomyxoviridae and include influenza virus types A, B, and C. This introduction provides an overview of influenza virus classification, structure, and life cycle. We also include a brief review of the clinical manifestations of influenza and the molecular determinants for virulence. The genetic diversity of influenza A viruses and their capability to successfully infect an array of hosts, including avian and mammalian species, are highlighted in a discussion about host range and evolution. The importance of viral receptor-binding hemagglutinins and host sialic acid distribution in speciesrestricted binding of viruses is underscored. Finally, recent advances in our understanding of the seasonality and transmission of influenza viruses are described, and their importance for the control of the spread of these viruses is discussed.
UR - http://www.scopus.com/inward/record.url?scp=79960057531&partnerID=8YFLogxK
U2 - 10.1007/978-3-0346-0279-2_1
DO - 10.1007/978-3-0346-0279-2_1
M3 - Chapter
AN - SCOPUS:79960057531
SN - 9783034602785
T3 - Birkhauser Advances in Infectious Diseases
SP - 3
EP - 26
BT - Influenza Vaccines for the Future
A2 - Rappuoli, Rino
A2 - Giudice, Giuseppe
ER -