Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication

Michael Bergmann, Adolfo Garcia-Sastre, Elena Carnero, Hubert Pehamberger, Klaus Wolff, Peter Palese, Thomas Muster

Research output: Contribution to journalArticlepeer-review

315 Scopus citations

Abstract

The availability of an influenza virus NS1 gene knockout virus (delNS1 virus) allowed us to establish the significance of the biological relationship between the influenza virus NS1 protein and double-stranded-RNA- activated protein kinase (PKR) in the life cycle and pathogenicity of influenza virus. Our results show that the lack of functional PKR permits the delNS1 virus to replicate in otherwise nonpermissive hosts, suggesting that the major function of the influenza virus NS1 protein is to counteract or prevent the PKR-mediated antiviral response.

Original languageEnglish
Pages (from-to)6203-6206
Number of pages4
JournalJournal of Virology
Volume74
Issue number13
DOIs
StatePublished - 2000
Externally publishedYes

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