Influenza C virus RNA 7 codes for a nonstructural protein

S. Nakada, P. N. Graves, U. Desselberger, R. S. Creager, M. Krystal, P. Palese

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


The complete nucleotide sequence of RNA segment 7 of influenza C/California/78 virus was determined by using cloned cDNA derived from viral RNA. The gene is 934 nucleotides long and possesses a long open reading frame which can code for a protein of 286 amino acids. Hybrid translation experiments with the cloned cDNA fragment and poly(A)-containing RNA isolated from virus-infected cells showed that a 28,500-molecular-weight protein is coded for by RNA 7. Comparison of the proteins induced in the cell-free system and in virus-infected cells with those found in purified virus suggested that the 28,500-molecular-weight protein is a nonstructural protein.

Original languageEnglish
Pages (from-to)221-226
Number of pages6
JournalJournal of Virology
Issue number1
StatePublished - 1985


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