Influenza B virus genome: assignment of viral polypeptides to RNA segments.

V. R. Racaniello, P. Palese

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

It was shown that all eight RNA segments of influenza B viruses are most likely monocistronic and code for eight virus-specific polypeptides. A genetic map of the influenza B virus genome was established, and six polypeptides (P1 protein, nucleoprotein, hemagglutinin, neuraminidase, M protein, and nonstructural protein) were unambiguously assigned to specific RNA segments. Molecular weight estimates of the eight individual genes are obtained by using the glyoxal method. These results suggest that each influenza B virus RNA segment has a greater molecular weight than the influenza A virus RNA segment which codes for the analogous gene product.

Original languageEnglish
Pages (from-to)361-373
Number of pages13
JournalJournal of Virology
Volume29
Issue number1
DOIs
StatePublished - Jan 1979

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