Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope

Goran Bajic; Max J. Maron; Yu Adachi; Taishi Onodera; Kevin R. McCarthy; Charles E. McGee; Gregory D. Sempowski; Yoshimasa Takahashi; Garnett Kelsoe; Masayuki Kuraoka; Aaron G. Schmidt

doi:10.1016/j.chom.2019.04.003

Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope

Goran Bajic
, Max J. Maron
, Yu Adachi
, Taishi Onodera
, Kevin R. McCarthy
, Charles E. McGee
, Gregory D. Sempowski
, Yoshimasa Takahashi
, Garnett Kelsoe
, Masayuki Kuraoka
, Aaron G. Schmidt

Research output: Contribution to journal › Article › peer-review

134 Scopus citations

Abstract

Eliciting protective immunity against influenza remains a major challenge. Bajic et al. show how hemagglutinin (HA) hyperglycosylation can restrict the resulting antibody repertoire to an occluded epitope at the HA head interface. These antibodies protect against influenza-virus challenge, providing insights into antigen engineering to alter antibody responses.

Original language	English
Pages (from-to)	827-835.e6
Journal	Cell Host and Microbe
Volume	25
Issue number	6
DOIs	https://doi.org/10.1016/j.chom.2019.04.003
State	Published - 12 Jun 2019
Externally published	Yes

Keywords

broadly neutralizing antibodies
immunogen design
influenza hemagglutinin
protein engineering

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10.1016/j.chom.2019.04.003

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@article{2409942dcd794018b3ee7c66d3db0a80,

title = "Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope",

abstract = "Eliciting protective immunity against influenza remains a major challenge. Bajic et al. show how hemagglutinin (HA) hyperglycosylation can restrict the resulting antibody repertoire to an occluded epitope at the HA head interface. These antibodies protect against influenza-virus challenge, providing insights into antigen engineering to alter antibody responses.",

keywords = "broadly neutralizing antibodies, immunogen design, influenza hemagglutinin, protein engineering",

author = "Goran Bajic and Maron, \{Max J.\} and Yu Adachi and Taishi Onodera and McCarthy, \{Kevin R.\} and McGee, \{Charles E.\} and Sempowski, \{Gregory D.\} and Yoshimasa Takahashi and Garnett Kelsoe and Masayuki Kuraoka and Schmidt, \{Aaron G.\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = jun,

day = "12",

doi = "10.1016/j.chom.2019.04.003",

language = "English",

volume = "25",

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journal = "Cell Host and Microbe",

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TY - JOUR

T1 - Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope

AU - Bajic, Goran

AU - Maron, Max J.

AU - Adachi, Yu

AU - Onodera, Taishi

AU - McCarthy, Kevin R.

AU - McGee, Charles E.

AU - Sempowski, Gregory D.

AU - Takahashi, Yoshimasa

AU - Kelsoe, Garnett

AU - Kuraoka, Masayuki

AU - Schmidt, Aaron G.

PY - 2019/6/12

Y1 - 2019/6/12

N2 - Eliciting protective immunity against influenza remains a major challenge. Bajic et al. show how hemagglutinin (HA) hyperglycosylation can restrict the resulting antibody repertoire to an occluded epitope at the HA head interface. These antibodies protect against influenza-virus challenge, providing insights into antigen engineering to alter antibody responses.

AB - Eliciting protective immunity against influenza remains a major challenge. Bajic et al. show how hemagglutinin (HA) hyperglycosylation can restrict the resulting antibody repertoire to an occluded epitope at the HA head interface. These antibodies protect against influenza-virus challenge, providing insights into antigen engineering to alter antibody responses.

KW - broadly neutralizing antibodies

KW - immunogen design

KW - influenza hemagglutinin

KW - protein engineering

UR - https://www.scopus.com/pages/publications/85065225320

U2 - 10.1016/j.chom.2019.04.003

DO - 10.1016/j.chom.2019.04.003

M3 - Article

C2 - 31104946

AN - SCOPUS:85065225320

SN - 1931-3128

VL - 25

SP - 827-835.e6

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 6

ER -

Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope

Abstract

Keywords

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