Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope

Goran Bajic; Max J. Maron; Yu Adachi; Taishi Onodera; Kevin R. McCarthy; Charles E. McGee; Gregory D. Sempowski; Yoshimasa Takahashi; Garnett Kelsoe; Masayuki Kuraoka; Aaron G. Schmidt

doi:10.1016/j.chom.2019.04.003

Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope

Goran Bajic, Max J. Maron, Yu Adachi, Taishi Onodera, Kevin R. McCarthy, Charles E. McGee, Gregory D. Sempowski, Yoshimasa Takahashi, Garnett Kelsoe, Masayuki Kuraoka, Aaron G. Schmidt

Research output: Contribution to journal › Article › peer-review

119 Scopus citations

Abstract

Eliciting protective immunity against influenza remains a major challenge. Bajic et al. show how hemagglutinin (HA) hyperglycosylation can restrict the resulting antibody repertoire to an occluded epitope at the HA head interface. These antibodies protect against influenza-virus challenge, providing insights into antigen engineering to alter antibody responses.

Original language	English
Pages (from-to)	827-835.e6
Journal	Cell Host and Microbe
Volume	25
Issue number	6
DOIs	https://doi.org/10.1016/j.chom.2019.04.003
State	Published - 12 Jun 2019
Externally published	Yes

Keywords

broadly neutralizing antibodies
immunogen design
influenza hemagglutinin
protein engineering

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10.1016/j.chom.2019.04.003

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title = "Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope",

abstract = "Eliciting protective immunity against influenza remains a major challenge. Bajic et al. show how hemagglutinin (HA) hyperglycosylation can restrict the resulting antibody repertoire to an occluded epitope at the HA head interface. These antibodies protect against influenza-virus challenge, providing insights into antigen engineering to alter antibody responses.",

keywords = "broadly neutralizing antibodies, immunogen design, influenza hemagglutinin, protein engineering",

author = "Goran Bajic and Maron, {Max J.} and Yu Adachi and Taishi Onodera and McCarthy, {Kevin R.} and McGee, {Charles E.} and Sempowski, {Gregory D.} and Yoshimasa Takahashi and Garnett Kelsoe and Masayuki Kuraoka and Schmidt, {Aaron G.}",

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doi = "10.1016/j.chom.2019.04.003",

language = "English",

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T1 - Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope

AU - Bajic, Goran

AU - Maron, Max J.

AU - Adachi, Yu

AU - Onodera, Taishi

AU - McCarthy, Kevin R.

AU - McGee, Charles E.

AU - Sempowski, Gregory D.

AU - Takahashi, Yoshimasa

AU - Kelsoe, Garnett

AU - Kuraoka, Masayuki

AU - Schmidt, Aaron G.

PY - 2019/6/12

Y1 - 2019/6/12

N2 - Eliciting protective immunity against influenza remains a major challenge. Bajic et al. show how hemagglutinin (HA) hyperglycosylation can restrict the resulting antibody repertoire to an occluded epitope at the HA head interface. These antibodies protect against influenza-virus challenge, providing insights into antigen engineering to alter antibody responses.

AB - Eliciting protective immunity against influenza remains a major challenge. Bajic et al. show how hemagglutinin (HA) hyperglycosylation can restrict the resulting antibody repertoire to an occluded epitope at the HA head interface. These antibodies protect against influenza-virus challenge, providing insights into antigen engineering to alter antibody responses.

KW - broadly neutralizing antibodies

KW - immunogen design

KW - influenza hemagglutinin

KW - protein engineering

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U2 - 10.1016/j.chom.2019.04.003

DO - 10.1016/j.chom.2019.04.003

M3 - Article

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SN - 1931-3128

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SP - 827-835.e6

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 6

ER -

Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope

Abstract

Keywords

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