Influenza A viruses expressing intra- or intergroup chimeric hemagglutinins

Chi Jene Chen, Megan E. Ermler, Gene S. Tan, Florian Krammer, Peter Palese, Rong Hai

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


A panel of influenza A viruses expressing chimeric hemagglutinins (cHA) with intragroup or intergroup head/stalk combinations was generated. Viruses were characterized for growth kinetics and preservation of stalk epitopes. With a few notable exceptions, cHA viruses behaved similarly to wild-type viruses and maintained stalk epitopes, which indicated their potential as vaccine candidates to induce stalk-specific antibodies.

Original languageEnglish
Pages (from-to)3789-3793
Number of pages5
JournalJournal of Virology
Issue number7
StatePublished - 2016


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