Influenza A viruses expressing intra- or intergroup chimeric hemagglutinins

Chi Jene Chen; Megan E. Ermler; Gene S. Tan; Florian Krammer; Peter Palese; Rong Hai

doi:10.1128/JVI.03060-15

Influenza A viruses expressing intra- or intergroup chimeric hemagglutinins

Chi Jene Chen, Megan E. Ermler, Gene S. Tan, Florian Krammer, Peter Palese, Rong Hai

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Abstract

A panel of influenza A viruses expressing chimeric hemagglutinins (cHA) with intragroup or intergroup head/stalk combinations was generated. Viruses were characterized for growth kinetics and preservation of stalk epitopes. With a few notable exceptions, cHA viruses behaved similarly to wild-type viruses and maintained stalk epitopes, which indicated their potential as vaccine candidates to induce stalk-specific antibodies.

Original language	English
Pages (from-to)	3789-3793
Number of pages	5
Journal	Journal of Virology
Volume	90
Issue number	7
DOIs	https://doi.org/10.1128/JVI.03060-15
State	Published - 2016

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title = "Influenza A viruses expressing intra- or intergroup chimeric hemagglutinins",

abstract = "A panel of influenza A viruses expressing chimeric hemagglutinins (cHA) with intragroup or intergroup head/stalk combinations was generated. Viruses were characterized for growth kinetics and preservation of stalk epitopes. With a few notable exceptions, cHA viruses behaved similarly to wild-type viruses and maintained stalk epitopes, which indicated their potential as vaccine candidates to induce stalk-specific antibodies.",

author = "Chen, {Chi Jene} and Ermler, {Megan E.} and Tan, {Gene S.} and Florian Krammer and Peter Palese and Rong Hai",

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AU - Krammer, Florian

AU - Palese, Peter

AU - Hai, Rong

PY - 2016

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AB - A panel of influenza A viruses expressing chimeric hemagglutinins (cHA) with intragroup or intergroup head/stalk combinations was generated. Viruses were characterized for growth kinetics and preservation of stalk epitopes. With a few notable exceptions, cHA viruses behaved similarly to wild-type viruses and maintained stalk epitopes, which indicated their potential as vaccine candidates to induce stalk-specific antibodies.

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Influenza A viruses expressing intra- or intergroup chimeric hemagglutinins

Abstract

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