Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets

Masaki Imai; Makoto Yamashita; Yuko Sakai-Tagawa; Kiyoko Iwatsuki-Horimoto; Maki Kiso; Jurika Murakami; Atsuhiro Yasuhara; Kosuke Takada; Mutsumi Ito; Noriko Nakajima; Kenta Takahashi; Tiago J.S. Lopes; Jayeeta Dutta; Zenab Khan; Divya Kriti; Harm van Bakel; Akifumi Tokita; Haruhisa Hagiwara; Naomi Izumida; Haruo Kuroki; Tamon Nishino; Noriyuki Wada; Michiko Koga; Eisuke Adachi; Daisuke Jubishi; Hideki Hasegawa; Yoshihiro Kawaoka

doi:10.1038/s41564-019-0609-0

Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets

Masaki Imai, Makoto Yamashita, Yuko Sakai-Tagawa, Kiyoko Iwatsuki-Horimoto, Maki Kiso, Jurika Murakami, Atsuhiro Yasuhara, Kosuke Takada, Mutsumi Ito, Noriko Nakajima, Kenta Takahashi, Tiago J.S. Lopes, Jayeeta Dutta, Zenab Khan, Divya Kriti, Harm van Bakel, Akifumi Tokita, Haruhisa Hagiwara, Naomi Izumida, Haruo KurokiTamon Nishino, Noriyuki Wada, Michiko Koga, Eisuke Adachi, Daisuke Jubishi, Hideki Hasegawa, Yoshihiro Kawaoka

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Abstract

Here we report the isolation of the influenza A/H1N1 2009 pandemic (A/H1N1pdm) and A/H3N2 viruses carrying an I38T mutation in the polymerase acidic protein—a mutation that confers reduced susceptibility to baloxavir marboxil—from patients before and after treatment with baloxavir marboxil in Japan. These variants showed replicative abilities and pathogenicity that is similar to those of wild-type isolates in hamsters; they also transmitted efficiently between ferrets by respiratory droplets.

Original language	English
Pages (from-to)	27-33
Number of pages	7
Journal	Nature Microbiology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1038/s41564-019-0609-0
State	Published - 1 Jan 2020

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Imai, M., Yamashita, M., Sakai-Tagawa, Y., Iwatsuki-Horimoto, K., Kiso, M., Murakami, J., Yasuhara, A., Takada, K., Ito, M., Nakajima, N., Takahashi, K., Lopes, T. J. S., Dutta, J., Khan, Z., Kriti, D., van Bakel, H., Tokita, A., Hagiwara, H., Izumida, N., ... Kawaoka, Y. (2020). Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets. Nature Microbiology, 5(1), 27-33. https://doi.org/10.1038/s41564-019-0609-0

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title = "Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets",

abstract = "Here we report the isolation of the influenza A/H1N1 2009 pandemic (A/H1N1pdm) and A/H3N2 viruses carrying an I38T mutation in the polymerase acidic protein—a mutation that confers reduced susceptibility to baloxavir marboxil—from patients before and after treatment with baloxavir marboxil in Japan. These variants showed replicative abilities and pathogenicity that is similar to those of wild-type isolates in hamsters; they also transmitted efficiently between ferrets by respiratory droplets.",

author = "Masaki Imai and Makoto Yamashita and Yuko Sakai-Tagawa and Kiyoko Iwatsuki-Horimoto and Maki Kiso and Jurika Murakami and Atsuhiro Yasuhara and Kosuke Takada and Mutsumi Ito and Noriko Nakajima and Kenta Takahashi and Lopes, {Tiago J.S.} and Jayeeta Dutta and Zenab Khan and Divya Kriti and {van Bakel}, Harm and Akifumi Tokita and Haruhisa Hagiwara and Naomi Izumida and Haruo Kuroki and Tamon Nishino and Noriyuki Wada and Michiko Koga and Eisuke Adachi and Daisuke Jubishi and Hideki Hasegawa and Yoshihiro Kawaoka",

note = "Publisher Copyright: {\textcopyright} 2019, The Author(s), under exclusive licence to Springer Nature Limited.",

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doi = "10.1038/s41564-019-0609-0",

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Imai, M, Yamashita, M, Sakai-Tagawa, Y, Iwatsuki-Horimoto, K, Kiso, M, Murakami, J, Yasuhara, A, Takada, K, Ito, M, Nakajima, N, Takahashi, K, Lopes, TJS, Dutta, J, Khan, Z, Kriti, D, van Bakel, H, Tokita, A, Hagiwara, H, Izumida, N, Kuroki, H, Nishino, T, Wada, N, Koga, M, Adachi, E, Jubishi, D, Hasegawa, H & Kawaoka, Y 2020, 'Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets', Nature Microbiology, vol. 5, no. 1, pp. 27-33. https://doi.org/10.1038/s41564-019-0609-0

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T1 - Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets

AU - Imai, Masaki

AU - Yamashita, Makoto

AU - Sakai-Tagawa, Yuko

AU - Iwatsuki-Horimoto, Kiyoko

AU - Kiso, Maki

AU - Murakami, Jurika

AU - Yasuhara, Atsuhiro

AU - Takada, Kosuke

AU - Ito, Mutsumi

AU - Nakajima, Noriko

AU - Takahashi, Kenta

AU - Lopes, Tiago J.S.

AU - Dutta, Jayeeta

AU - Khan, Zenab

AU - Kriti, Divya

AU - van Bakel, Harm

AU - Tokita, Akifumi

AU - Hagiwara, Haruhisa

AU - Izumida, Naomi

AU - Kuroki, Haruo

AU - Nishino, Tamon

AU - Wada, Noriyuki

AU - Koga, Michiko

AU - Adachi, Eisuke

AU - Jubishi, Daisuke

AU - Hasegawa, Hideki

AU - Kawaoka, Yoshihiro

PY - 2020/1/1

Y1 - 2020/1/1

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AB - Here we report the isolation of the influenza A/H1N1 2009 pandemic (A/H1N1pdm) and A/H3N2 viruses carrying an I38T mutation in the polymerase acidic protein—a mutation that confers reduced susceptibility to baloxavir marboxil—from patients before and after treatment with baloxavir marboxil in Japan. These variants showed replicative abilities and pathogenicity that is similar to those of wild-type isolates in hamsters; they also transmitted efficiently between ferrets by respiratory droplets.

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JF - Nature Microbiology

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ER -

Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets

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