Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach

Julie Talon, Mirella Salvatore, Robert E. O'Neill, Yurie Nakaya, Hongyong Zheng, Thomas Muster, Adolfo Garcia-Sastre, Peter Palese

Research output: Contribution to journalArticlepeer-review

279 Scopus citations


We propose a rational approach to the generation of live viral vaccines: alteration of virally encoded type I IFN antagonists to attenuate virulence while retaining immunogenicity. We have explored this concept by using the influenza virus. Previously we have shown that the NS1 protein of influenza A virus possesses anti-IFN activity. We now present evidence that influenza A and B viruses encoding altered viral NS1 proteins are highly attenuated in the mouse host, yet provide protection from challenge with wild-type viruses.

Original languageEnglish
Pages (from-to)4309-4314
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number8
StatePublished - 11 Apr 2000


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