Influence of White Matter Anisotropy on the Effects of Transcranial Direct Current Stimulation: A Finite Element Study

W. H. Lee; H. S. Seo; S. H. Kim; M. H. Cho; S. Y. Lee; T. S. Kim

doi:10.1007/978-3-540-92841-6_113

Influence of White Matter Anisotropy on the Effects of Transcranial Direct Current Stimulation: A Finite Element Study

W. H. Lee, H. S. Seo, S. H. Kim, M. H. Cho, S. Y. Lee, T. S. Kim

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

9 Scopus citations

Abstract

Although the use of transcranial direct current stimulation (tDCS), a noninvasive brain stimulation technique, has become popular in cognitive neuroscience research and clinical applications, there still exists limited knowledge on how to optimally use tDCS for the brain stimulation. To understand the underlying principles and effects of tDCS, finite element analysis (FEA) has been successfully applied due to its truly volumetric analysis and capability of incorporating the anisotropic tissue property. However, there are still many factors to be considered in stimulation: the influence of the white matter (WM) anisotropy is one of them which has not been considered in tDCS. In this study, we have examined the influence of the WM anisotropic conductivities on tDCS via high-resolution FE head models of the whole head. The effects of the WM anisotropy has been assessed by comparing the current density maps computed from the anisotropic FE model against those of the isotropic model using the similarity measures. The results show that there are significant differences caused by the tissue anisotropy, indicating that the anisotropic electrical conductivity is one of the critical factors to be considered during tDCS for accurate and effective stimulation of the brain.

Original language	English
Title of host publication	13th International Conference on Biomedical Engineering - ICBME 2008
Pages	460-464
Number of pages	5
DOIs	https://doi.org/10.1007/978-3-540-92841-6_113
State	Published - 2009
Externally published	Yes
Event	13th International Conference on Biomedical Engineering, ICBME 2008 - , Singapore Duration: 3 Dec 2008 → 6 Dec 2008

Publication series

Name	IFMBE Proceedings
Volume	23
ISSN (Print)	1680-0737

Conference

Conference	13th International Conference on Biomedical Engineering, ICBME 2008
Country/Territory	Singapore
Period	3/12/08 → 6/12/08

Keywords

Finite element analysis
Transcranial direct current stimulation
White matter anisotropic conductivity

Access to Document

10.1007/978-3-540-92841-6_113

Cite this

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title = "Influence of White Matter Anisotropy on the Effects of Transcranial Direct Current Stimulation: A Finite Element Study",

abstract = "Although the use of transcranial direct current stimulation (tDCS), a noninvasive brain stimulation technique, has become popular in cognitive neuroscience research and clinical applications, there still exists limited knowledge on how to optimally use tDCS for the brain stimulation. To understand the underlying principles and effects of tDCS, finite element analysis (FEA) has been successfully applied due to its truly volumetric analysis and capability of incorporating the anisotropic tissue property. However, there are still many factors to be considered in stimulation: the influence of the white matter (WM) anisotropy is one of them which has not been considered in tDCS. In this study, we have examined the influence of the WM anisotropic conductivities on tDCS via high-resolution FE head models of the whole head. The effects of the WM anisotropy has been assessed by comparing the current density maps computed from the anisotropic FE model against those of the isotropic model using the similarity measures. The results show that there are significant differences caused by the tissue anisotropy, indicating that the anisotropic electrical conductivity is one of the critical factors to be considered during tDCS for accurate and effective stimulation of the brain.",

keywords = "Finite element analysis, Transcranial direct current stimulation, White matter anisotropic conductivity",

author = "Lee, {W. H.} and Seo, {H. S.} and Kim, {S. H.} and Cho, {M. H.} and Lee, {S. Y.} and Kim, {T. S.}",

year = "2009",

doi = "10.1007/978-3-540-92841-6_113",

language = "English",

isbn = "9783540928409",

series = "IFMBE Proceedings",

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Lee, WH, Seo, HS, Kim, SH, Cho, MH, Lee, SY & Kim, TS 2009, Influence of White Matter Anisotropy on the Effects of Transcranial Direct Current Stimulation: A Finite Element Study. in 13th International Conference on Biomedical Engineering - ICBME 2008. IFMBE Proceedings, vol. 23, pp. 460-464, 13th International Conference on Biomedical Engineering, ICBME 2008, Singapore, 3/12/08. https://doi.org/10.1007/978-3-540-92841-6_113

Influence of White Matter Anisotropy on the Effects of Transcranial Direct Current Stimulation: A Finite Element Study. / Lee, W. H.; Seo, H. S.; Kim, S. H. et al.
13th International Conference on Biomedical Engineering - ICBME 2008. 2009. p. 460-464 (IFMBE Proceedings; Vol. 23).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AB - Although the use of transcranial direct current stimulation (tDCS), a noninvasive brain stimulation technique, has become popular in cognitive neuroscience research and clinical applications, there still exists limited knowledge on how to optimally use tDCS for the brain stimulation. To understand the underlying principles and effects of tDCS, finite element analysis (FEA) has been successfully applied due to its truly volumetric analysis and capability of incorporating the anisotropic tissue property. However, there are still many factors to be considered in stimulation: the influence of the white matter (WM) anisotropy is one of them which has not been considered in tDCS. In this study, we have examined the influence of the WM anisotropic conductivities on tDCS via high-resolution FE head models of the whole head. The effects of the WM anisotropy has been assessed by comparing the current density maps computed from the anisotropic FE model against those of the isotropic model using the similarity measures. The results show that there are significant differences caused by the tissue anisotropy, indicating that the anisotropic electrical conductivity is one of the critical factors to be considered during tDCS for accurate and effective stimulation of the brain.

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Influence of White Matter Anisotropy on the Effects of Transcranial Direct Current Stimulation: A Finite Element Study

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