Influence of the Rh (D) blood group system on graft survival in renal transplantation

Christopher F. Bryan; Stanley I. Mitchell; Hung Mo Lin; Paul W. Nelson; Charles F. Shield; Alan M. Luger; George E. Pierce; Gilbert Ross; Bradley A. Warady; Mark I. Aeder; Thomas S. Helling; Michael D. Landreneau; Kevin M. Harrell

doi:10.1097/00007890-199802270-00026

Influence of the Rh (D) blood group system on graft survival in renal transplantation

Christopher F. Bryan, Stanley I. Mitchell, Hung Mo Lin, Paul W. Nelson, Charles F. Shield, Alan M. Luger, George E. Pierce, Gilbert Ross, Bradley A. Warady, Mark I. Aeder, Thomas S. Helling, Michael D. Landreneau, Kevin M. Harrell

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Background: The Rh (D) blood group system has not traditionally been considered to be a clinically relevant histocompatibility barrier in transplantation since conflicting results of its clinical importance have been reported. Methods: We analyzed 786 consecutive primary cadaveric renal transplants performed by transplant centers in our Organ Procurement Organization (OPO) between 1990 and 1996. We also analyzed United Network for Organ Sharing (UNOS) data on 26,469 kidney transplants done from April 1994 to June 1996. Results: Multivariate analysis revealed that Rh identity between the recipient and donor was significantly related to better graft outcome (risk ratio, 0.43; 95% confidence interval, 0.30 to 0.61; P=0.0001). Multivariate analysis of the UNOS data revealed that the Rh -/- group may have a positive influence on graft survival with a risk ratio of 0.43 (P=0.14). Conclusion: Multivariate analysis of primary cadaveric renal allografts performed within the Midwest Organ Bank OPO indicates that Rh (D) is a clinically relevant histocompatibility barrier that influences 7-year graft survival.

Original language	English
Pages (from-to)	588-592
Number of pages	5
Journal	Transplantation
Volume	65
Issue number	4
DOIs	https://doi.org/10.1097/00007890-199802270-00026
State	Published - 27 Feb 1998
Externally published	Yes

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title = "Influence of the Rh (D) blood group system on graft survival in renal transplantation",

abstract = "Background: The Rh (D) blood group system has not traditionally been considered to be a clinically relevant histocompatibility barrier in transplantation since conflicting results of its clinical importance have been reported. Methods: We analyzed 786 consecutive primary cadaveric renal transplants performed by transplant centers in our Organ Procurement Organization (OPO) between 1990 and 1996. We also analyzed United Network for Organ Sharing (UNOS) data on 26,469 kidney transplants done from April 1994 to June 1996. Results: Multivariate analysis revealed that Rh identity between the recipient and donor was significantly related to better graft outcome (risk ratio, 0.43; 95% confidence interval, 0.30 to 0.61; P=0.0001). Multivariate analysis of the UNOS data revealed that the Rh -/- group may have a positive influence on graft survival with a risk ratio of 0.43 (P=0.14). Conclusion: Multivariate analysis of primary cadaveric renal allografts performed within the Midwest Organ Bank OPO indicates that Rh (D) is a clinically relevant histocompatibility barrier that influences 7-year graft survival.",

author = "Bryan, {Christopher F.} and Mitchell, {Stanley I.} and Lin, {Hung Mo} and Nelson, {Paul W.} and Shield, {Charles F.} and Luger, {Alan M.} and Pierce, {George E.} and Gilbert Ross and Warady, {Bradley A.} and Aeder, {Mark I.} and Helling, {Thomas S.} and Landreneau, {Michael D.} and Harrell, {Kevin M.}",

year = "1998",

month = feb,

day = "27",

doi = "10.1097/00007890-199802270-00026",

language = "English",

volume = "65",

pages = "588--592",

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T1 - Influence of the Rh (D) blood group system on graft survival in renal transplantation

AU - Bryan, Christopher F.

AU - Mitchell, Stanley I.

AU - Lin, Hung Mo

AU - Nelson, Paul W.

AU - Shield, Charles F.

AU - Luger, Alan M.

AU - Pierce, George E.

AU - Ross, Gilbert

AU - Warady, Bradley A.

AU - Aeder, Mark I.

AU - Helling, Thomas S.

AU - Landreneau, Michael D.

AU - Harrell, Kevin M.

PY - 1998/2/27

Y1 - 1998/2/27

N2 - Background: The Rh (D) blood group system has not traditionally been considered to be a clinically relevant histocompatibility barrier in transplantation since conflicting results of its clinical importance have been reported. Methods: We analyzed 786 consecutive primary cadaveric renal transplants performed by transplant centers in our Organ Procurement Organization (OPO) between 1990 and 1996. We also analyzed United Network for Organ Sharing (UNOS) data on 26,469 kidney transplants done from April 1994 to June 1996. Results: Multivariate analysis revealed that Rh identity between the recipient and donor was significantly related to better graft outcome (risk ratio, 0.43; 95% confidence interval, 0.30 to 0.61; P=0.0001). Multivariate analysis of the UNOS data revealed that the Rh -/- group may have a positive influence on graft survival with a risk ratio of 0.43 (P=0.14). Conclusion: Multivariate analysis of primary cadaveric renal allografts performed within the Midwest Organ Bank OPO indicates that Rh (D) is a clinically relevant histocompatibility barrier that influences 7-year graft survival.

AB - Background: The Rh (D) blood group system has not traditionally been considered to be a clinically relevant histocompatibility barrier in transplantation since conflicting results of its clinical importance have been reported. Methods: We analyzed 786 consecutive primary cadaveric renal transplants performed by transplant centers in our Organ Procurement Organization (OPO) between 1990 and 1996. We also analyzed United Network for Organ Sharing (UNOS) data on 26,469 kidney transplants done from April 1994 to June 1996. Results: Multivariate analysis revealed that Rh identity between the recipient and donor was significantly related to better graft outcome (risk ratio, 0.43; 95% confidence interval, 0.30 to 0.61; P=0.0001). Multivariate analysis of the UNOS data revealed that the Rh -/- group may have a positive influence on graft survival with a risk ratio of 0.43 (P=0.14). Conclusion: Multivariate analysis of primary cadaveric renal allografts performed within the Midwest Organ Bank OPO indicates that Rh (D) is a clinically relevant histocompatibility barrier that influences 7-year graft survival.

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DO - 10.1097/00007890-199802270-00026

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SN - 0041-1337

VL - 65

SP - 588

EP - 592

JO - Transplantation

JF - Transplantation

IS - 4

ER -

Influence of the Rh (D) blood group system on graft survival in renal transplantation

Abstract

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