Influence of the aortic component of the second heart sound on left ventricular maximal negative dP dt in the dog

Damon Smith, Ernest Craige

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Maximal negative left ventricular dP dt is widely used as a measure of isovolumic muscular relaxation of the left ventricle. In the course of canine experiments designed to elucidate the hemodynamic events responsible for the aortic component of the second heart sound, high-fidelity left ventricular pressure and dP dt signals were recorded and accelerations detected on the root of the aorta and epicardium at the cardiac apex. The second heart sound was coincident with maximal negative dP dt and affected its magnitude to a variable and unpredictable extent. This may account for some of the unexpected variations in magnitude of maximal negative dP dt that have been described in various disease states and in laboratory experiments where the effects of physiologic and pharmacologic interventions have been studied.

Original languageEnglish
Pages (from-to)205-209
Number of pages5
JournalAmerican Journal of Cardiology
Volume55
Issue number1
DOIs
StatePublished - 1 Jan 1985
Externally publishedYes

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