TY - JOUR
T1 - Influence of sleep on physiological systems in atherosclerosis
AU - Kiss, Máté G.
AU - Cohen, Oren
AU - McAlpine, Cameron S.
AU - Swirski, Filip K.
N1 - Publisher Copyright:
© Springer Nature Limited 2024.
PY - 2024/11
Y1 - 2024/11
N2 - Sleep is a fundamental requirement of life and is integral to health. Deviation from optimal sleep associates with numerous diseases including those of the cardiovascular system. Studies, spanning animal models to humans, show that insufficient, disrupted or inconsistent sleep contribute to poor cardiovascular health by disrupting body systems. Fundamental experiments have begun to uncover the molecular and cellular links between sleep and heart health while large-scale human studies have associated sleep with cardiovascular outcomes in diverse populations. Here, we review preclinical and clinical findings that demonstrate how sleep influences the autonomic nervous, metabolic and immune systems to affect atherosclerotic cardiovascular disease.
AB - Sleep is a fundamental requirement of life and is integral to health. Deviation from optimal sleep associates with numerous diseases including those of the cardiovascular system. Studies, spanning animal models to humans, show that insufficient, disrupted or inconsistent sleep contribute to poor cardiovascular health by disrupting body systems. Fundamental experiments have begun to uncover the molecular and cellular links between sleep and heart health while large-scale human studies have associated sleep with cardiovascular outcomes in diverse populations. Here, we review preclinical and clinical findings that demonstrate how sleep influences the autonomic nervous, metabolic and immune systems to affect atherosclerotic cardiovascular disease.
UR - http://www.scopus.com/inward/record.url?scp=85210444297&partnerID=8YFLogxK
U2 - 10.1038/s44161-024-00560-7
DO - 10.1038/s44161-024-00560-7
M3 - Review article
AN - SCOPUS:85210444297
SN - 2731-0590
VL - 3
SP - 1284
EP - 1300
JO - Nature Cardiovascular Research
JF - Nature Cardiovascular Research
IS - 11
ER -